May 1, 1976

Capability of lymphocytes, stimulated in vitro with phytohemagglutinins to accomplish the graft versus host reaction

Biulleten' eksperimental'noĭ biologii i meditsiny
V G Nesterenko, L V Koval'chuk

Abstract

Lymph node cells from CBA mice cultivated in the presence of PHA for 2 hours proved to be more potent, and for 44 hours--less potent as compared with normal non-cultivated cells in their capacity to realize the GVHR after injection to sublethally irradiated (CBAXC57BL) F1 recipients. Syngeneic or killed allogeneic lymphocytes cultivated similarly and phytohemagglutinin were found to be deprived of this potency.

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Mentioned in this Paper

Mice, Inbred CBA
Lymphoid Cells
Graft Vs Host Reaction
Lymphocyte Activation
Transplantation, Homologous
Animal Lectins
Lymphocyte Transfusion

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