Capacitative Ca2+ influx in the neural retina of chick embryo

Journal of Neurobiology
Y SakakiM Yamashita

Abstract

Depletion of intracellular Ca2+ stores induces a capacitative Ca2+ influx in non-neural cells. It has been unknown whether the capacitative Ca2+ influx occurs in the cells of nervous systems. We found the capacitative Ca2+ influx in the neural retina of early embryonic chick with Fura-2 fluorescence measurements. A Ca(2+)-free medium containing thapsigargin (500 nM), an inhibitor of Ca(2+)-ATPase of intracellular Ca2+ stores, was applied to the neural retina of embryonic day 3 (E3) chick. A rise in intracellular Ca2+ concentration was evoked after the reintroduction of extracellular Ca2+, and this Ca2+ rise was suppressed by Zn2+ (1 mM) and Ni2+ (5 mM). The developmental changes in the Ca2+ rise induced by thapsigargin (250 nM) were studied from E3 to E13. The thapsigargin-induced Ca2+ rise was largest at E3, declined rapidly toward E6, and then decreased gradually until E13, when the Ca2+ rise almost disappeared. This developmental profile correlated with the decline in the mitotic activities of the retinal cells studied by Prada et al. The fluorescence imaging with the vertical slice of the E9 retina showed that the site at which the thapsigargin-induced Ca2+ rise was largest was the most outer layer of the retina, where prol...Continue Reading

References

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Citations

Mar 27, 2003·Neuroscience Research·Miho Sugioka, Masayuki Yamashita
Jun 17, 1998·Neuroscience Letters·J IchikawaM Yamashita
May 15, 2002·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Glauco SanchesAna Lucia Marques Ventura
Aug 19, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M SugiokaM Yamashita
Feb 8, 2011·Biochemical and Biophysical Research Communications·Masayuki Yamashita
Aug 1, 2012·Stem Cells International·Masayuki Yamashita
Aug 12, 1998·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·G Sanches, A L Ventura
Feb 19, 1998·Journal of Neurobiology·M SugiokaM Yamashita
Aug 4, 2006·The FEBS Journal·Masayuki YamashitaYoichi Ogawa
May 18, 2000·Cell Biochemistry and Function·J IchikawaT Kiyohara
Jun 8, 2001·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Masayuki Yamashita, Miho Sugioka
Aug 16, 2012·Archives of Biochemistry and Biophysics·Masayuki Yamashita

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