Capacitive-like photovoltaic epiretinal stimulation enhances and narrows the network-mediated activity of retinal ganglion cells by recruiting the lateral inhibitory network

Journal of Neural Engineering
Naïg Aurelia Ludmilla ChenaisDiego Ghezzi

Abstract

Photovoltaic retinal prostheses theoretically offer the possibility of stand-alone high-resolution electrical stimulation of the retina. However, achieving focused epiretinal stimulation is particularly challenging because of axonal activation and electrical cell coupling. Recent evidence shows that long electric pulses permit a more focal activation of retinal ganglion cells, and non-rectangular waveforms induce higher network-mediated indirect activity. The role of the pulse shape in focusing the retinal ganglion cell activation and the underlying mechanisms are not yet fully understood. To address this question, we implemented a hybrid ex vivo and in silico approach. We recorded the evoked activity of retinas explanted from retinal degeneration ten mice upon photovoltaic and electrical stimulation with rectangular or non-rectangular capacitive-like voltage pulses. We used a biophysical model to investigate the role of the pulse shape and the pulse duration on the genesis and the extent of the network-mediated activity in retinal ganglion cells. Altogether, our results suggest that non-rectangular capacitive-like voltage pulses activate more strongly the inner excitatory and inhibitory layers of the retina, when compared to a...Continue Reading

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Citations

Oct 6, 2020·Biomedical Optics Express·Shashi Bhushan SrivastavaSedat Nizamoglu
Jan 2, 2021·Translational Vision Science & Technology·Samuel A TitchenerMatthew A Petoe
Nov 25, 2020·Journal of Neural Engineering·Naïg Aurélia Lüdmilla ChenaisDiego Ghezzi
Jul 27, 2021·ACS Applied Materials & Interfaces·Greta ChiaravalliGuglielmo Lanzani

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