Capecitabine lipid nanoparticles for anti-colon cancer activity in 1,2-dimethylhydrazine-induced colon cancer: preparation, cytotoxic, pharmacokinetic, and pathological evaluation

Drug Development and Industrial Pharmacy
Narendar Dudhipala, Goverdhan Puchchakayala

Abstract

The cornerstone of this investigation is to determine the pharmacokinetic and histopathological behavior of solid lipid nanoparticles of capecitabine (CB-SLNs) in 1,2-dimethylhydrazine (DMH) induced colon cancer. The nanoparticles were prepared by microemulsion method. CB-SLNs were characterized for an optimal system. The cytotoxicity of CB-SLNs was evaluated by using MTT assay method. Further, pharmacokinetic and histopathological behavior of SLNs were studied in DMH induced colon cancer rats. The optimized nanoparticles have the particle size, zeta potential, and entrapment efficiency of 145.6 ± 3.6 nm, -26.9 ± 2.7 mV, and 88.33 ± 3.74%, respectively. Particles of CB were nearly spherical in shape and converted to amorphous form revealed by SEM and DSC, XRD studies. The nanoparticles showed dose-dependent cytotoxicity activity from 10 to 125 µg/mL compared with suspension. Pharmacokinetic studies revealed that 2.7-folds enhancement in the oral bioavailability and in aberrant crypt foci number, apoptotic index comparison with suspension formulation.

References

May 1, 1989·British Journal of Cancer·J F ChesterS A Weitzman
Aug 15, 1998·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·A zur MühlenW Mehnert
May 20, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·S C YangC Z Yang
Jun 7, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·R H MüllerS Gohla
Apr 20, 2001·Advanced Drug Delivery Reviews·W Mehnert, K Mäder
Aug 8, 2001·Advanced Drug Delivery Reviews·C J Porter, W N Charman
Mar 15, 2005·Clinical Therapeutics·Christine M Walko, Celeste Lindley
Jul 12, 2005·Annales D'urologie·P BuissonY Héloury
Nov 1, 2005·The Lancet Oncology·Joseph J Y SungUNKNOWN Asia Pacific Working Group on Colorectal Cancer
May 24, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Arik Dahan, Amnon Hoffman
Nov 26, 2010·International Journal of Medical Sciences·Alaa Eldeen B YassinIbrahim A Alsarra
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayDonald Maxwell Parkin
May 6, 2011·Nanomedicine·Si-Shen FengJintian Tang
Dec 12, 2012·Advanced Drug Delivery Reviews·Lin MeiSi-Shen Feng
Feb 26, 2014·Drug Development and Industrial Pharmacy·Piyush Kumar SahuAshish Kumar Jain
Apr 2, 2015·Drug Development and Industrial Pharmacy·Narendar Dudhipala, Kishan Veerabrahma
Nov 1, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Bivash MandalGeorge C Wood
Nov 5, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Narendar Dudhipala, Kishan Veerabrahma
Apr 4, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Dawei GuoLiping Wang
Nov 9, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Maqsood Ur RehmanMunasib Khan

❮ Previous
Next ❯

Citations

Jan 24, 2019·AAPS PharmSciTech·Nikhar VishwakarmaSuresh P Vyas
Mar 27, 2019·Nanomaterials·Laura Bayón-CorderoLide Arana
Jul 2, 2019·Seminars in Cancer Biology·Eluri PavitraYun Suk Huh
Apr 30, 2021·International Journal of Pharmaceutics·Matte Kasi ViswanadhMadaswamy S Muthu
Jun 13, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·N A Bhaskaran, L Kumar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.