Capillaroscopic pattern in systemic sclerosis - an association with dynamics of processes of angio- and vasculogenesis

Microvascular Research
Sevdalina N Lambova, Ulf Müller-Ladner

Abstract

Мicrocirculation is the main environment of the pathologic processes in systemic sclerosis (SSc). Nailfold capillaroscopic abnormalities in SSc are highly specific. It is well known that capillaroscopic examination reveals different changes in the different stages of SSc. Dilated, single giant capillaries and haemorrhages, preserved arrangement are the characteristic features of the "early" capillaroscopic phase; frequent giant capillaries and haemorrhages are the findings in the "active" phase, while in the "late" stages extensive avascular areas are usually found. Although tissue hypoxia normally is a strong inducer of neovascularization, there is no evidence of significant vascular recovery in SSc patients. Formation of new blood vessels is possible through two different mechanisms - angiogenesis (formation of new vessels from differentiated endothelial cells of prior vessels) - and vasculogenesis (from endothelial progenitor cells-EPCs). Disturbed function of EPCs has been found in all the stages of the disease. Only EPCs from SSc patients in the early phase of the disease have shown preserved ability for differentiation and maturation to endothelial cells in vitro. The recovery of the injured microvessels is also disturbed...Continue Reading

Citations

Oct 16, 2012·Current Rheumatology Reports·Lesley Ann Saketkoo, Oliver Distler
Nov 16, 2011·Current Rheumatology Reports·Bradley J Rabquer, Alisa E Koch
May 24, 2014·The American Journal of the Medical Sciences·Marco SebastianiClodoveo Ferri
Nov 15, 2011·Rheumatic Diseases Clinics of North America·Judith F Ashouri, David I Daikh
Mar 31, 2012·Clinical Oral Implants Research·Asami UdagawaKoichi Ito
Dec 9, 2014·Autoimmunity Reviews·Inês ChoraRaquel Soares
Feb 28, 2016·Clinical Rheumatology·Ivone SilvaCarlos Vasconcelos
Dec 7, 2019·International Journal of Rheumatic Diseases·Sevdalina Nikolova Lambova, Ulf Müller-Ladner
Sep 15, 2020·Clinical Hemorheology and Microcirculation·Serkan YükselMurat Meriç
Jun 6, 2021·Clinical and Experimental Dermatology·S Arslan UkuE Inan Yuksel

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