PMID: 1211446Sep 1, 1975Paper

Capillary and cell wall permeability to potassium in isolated dog hearts

The American Journal of Physiology
R G TancrediJ B Bassingthwaighte

Abstract

From venous tracer-dilution curves recorded after 36 pulse injections of 42KCl and 131I-labeled albumin into the coronary artery inflow of 15 isolated canine heart preparations, we calculated maximal fractional extractions (Emax) and capillary permeability-surface area products (PScap) for 42K+ over a range of plasma flows (FP) from 0.3 to 1.7 ml min-1 g-u. At low FP (less than 1.0), Emax was 0.60 +/- 0.0l (mean +/- SD) and PScap was 0.72 +/- 0.20 ml min-1 g-1; at high FP (greater than 1.0), Emax decreased to 0.49 +/- 0.05 and PScap increased to 1.06 +/- 0.18. Continuous recording (gamma detector) of residual myocardial 42K+ in seven hearts showed that the mean fractional escape rate of tracer between 30 and 60 min after injection was 0.011-0.023 min-1; higher rates were observed at high FP, when the residue of 42K+ decreased to less than 10% of the injected dose by 60 min. Using PScap measured at high FP and considering the virtual intracellular volume of distribution for K+ to be 20 ml/g, we calculated the permeability-surface area product for sarcolemma (PScw) as 0.54-0.73 ml min-1 g-1, or about 50% of PScap. Considering sarcolemmal surface area (Scw) as 4,200 cm2/g and capillary surface area (Scap) as 500 cm2/g, cell permea...Continue Reading

Citations

Mar 23, 2000·Cardiovascular Research·F W Prinzen, J B Bassingthwaighte
Feb 1, 1978·The Journal of General Physiology·C CroneO Christensen
Jan 1, 1986·Physics in Medicine and Biology·R W Leggett, L R Williams
Sep 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C Y TongJ Wills
Mar 17, 2005·NMR in Biomedicine·Valery V Kupriyanov, Marco L H Gruwel
Jan 1, 1979·Annals of Biomedical Engineering·R J Roselli, T R Harris
Apr 21, 2001·Nuclear Medicine Communications·N D Charkes
Jan 1, 2010·Nano Reviews·Adam M AlessioJames B Bassingthwaighte
Aug 1, 1981·Circulation Research·D CousineauC A Goresky

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