Capillary blood cell velocity in periulcerous regions of the lower leg measured by laser Doppler anemometry

Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
Markus StückerPeter Altmeyer

Abstract

The capillary blood flow of the nailfold can be measured by means of modern non-invasive techniques like the videocapillary microscope in vivo. To quantify the capillary blood cell velocity, apart from the nailfold capillaries, we used a new technique, the so-called laser Doppler anemometry (LDA). The present study investigated how far laser Doppler fluxmetry (LDF), transcutaneous partial pressure of oxygen (tcpO2), and LDA are capable of quantifying differences of cutaneous microcirculation between patients with leg ulcera and a healthy control group. The effects of intravenous prostaglandin E1 and pentoxifylline were also investigated. Ten patients with venous leg ulcers and 10 patients with mixed venous/arterial ulcers were investigated with LDF, tcpO2, and LDA before and after injection of prostaglandin E1 and pentoxifylline. We measured the resting capillary blood cell velocity (rCBV), the maximum hyperemia, and the time to peak capillary blood cell velocity (tpCBV) during hyperemia after 4 min of suprasystolic occlusion and compared them with the results of a contol group of 20 patients. Laser Doppler flow was increased in all patients during resting period, whereas the tcpO2 was significantly decreased. LDF did not show ...Continue Reading

Citations

Jul 16, 2008·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·J Dissemond
Jun 26, 2012·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Domoina RatovosonVincent Huon
Apr 3, 2015·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Dereck W PaulJeffrey W Shupp
Jun 13, 2015·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·You Leo Li, Jeremy J Dahl
Jan 22, 2008·Dermatology : International Journal for Clinical and Investigative Dermatology·A KörberJ Dissemond
Oct 14, 2016·Biomechanics and Modeling in Mechanobiology·Wolfgang WiedemairVartan Kurtcuoglu
Dec 25, 2007·Advances in Skin & Wound Care·Jacqueline HuberDavid Huber
May 28, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Moritz Jörg SchneiderOlaf Dietrich
Nov 9, 2019·Advances in Wound Care·Rebecca KwasinskiAnuradha Godavarty

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