Capillary electrophoresis for the assay of fixed-dose combination tablets of artesunate and amodiaquine.

Malaria Journal
N'Cho Christophe AminHuguette Fabre

Abstract

Quality control of drugs in formulations is still a major challenge in developing countries. For the quality control of artesunate and amodiaquine tablets in fixed-dose combination, only liquid chromatographic methods have been proposed in the literature. There are no capillary electrophoretic methods reported for the determination of these active substances, although this technique presents several advantages over liquid chromatography (long lifetime, low price of the capillary, low volumes of electrolyte consumption) in addition to simplicity. In this paper, a reliable capillary electrophoresis method has been developed and validated for the quality control of these drugs in commercial fixed-dose combination tablets. Artesunate and amodiaquine hydrochloride in bilayer tablets were determined by micellar electrokinetic capillary chromatography (MEKC). Analytes were extracted from tablets by sonication with a solvent mixture phosphate buffer pH 7.0-acetonitrile containing benzoic acid as internal standard. Separation was carried out on Beckman capillary electrophoresis system equipped with fused silica capillary, 30 cm long (20 cm to detector) × 50 μm internal diameter, using a 25 mM borate buffer pH 9.2 containing 30 mM sodium...Continue Reading

References

Jun 1, 1996·Journal of Pharmaceutical Sciences·P AugustijnsR Kinget
Mar 4, 2000·Journal of Pharmaceutical and Biomedical Analysis·M GabriëlsJ Plaizier-Vercammen
Nov 7, 2006·Journal of Pharmaceutical and Biomedical Analysis·Karen GaudinJean-Pierre Dubost
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Oct 26, 2010·Journal of Pharmaceutical and Biomedical Analysis·Ben BardsleyMagdalena M Szafran

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Citations

Feb 5, 2013·Journal of Chromatographic Science·Eric DeconinckJacques O De Beer
May 2, 2017·Chemical & Pharmaceutical Bulletin·Naoya MatsuzakiShigeru Itai
Nov 20, 2020·Analytical Methods : Advancing Methods and Applications·Jéssica Cordeiro Queiroz de SouzaMarcone Augusto Leal de Oliveira

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Methods Mentioned

BETA
electrophoresis
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