PMID: 7539589May 1, 1995Paper

Capillary hydraulic conductivity is decreased by nitric oxide synthase inhibition

The American Journal of Physiology
Rolando E RumbautVirginia H Huxley

Abstract

Nitric oxide (NO) has been reported to modulate microvascular permeability to solutes in whole organs, venules, and cultured endothelial cell monolayers. NO derived from L-arginine via NO synthase activates soluble guanylate cyclase in vascular smooth muscle and endothelial cells. While the effects of NO on capillary water permeability have not been characterized, other activators of guanylate cyclase, such as sodium nitroprusside and atrial natriuretic peptide, increase capillary hydraulic conductivity (Lp). We hypothesized that inhibition of NO synthase with the arginine analogue, NG-monomethyl-L-arginine (L-NMMA), would decrease Lp from control levels. Lp was assessed in situ in single perfused frog mesenteric capillaries, first during control conditions (Lcontrolp) and then during superfusion (Ltestp) with either L-NMMA, NG-monomethyl-D-arginine (D-NMMA), a biologically inert enantiomer, or L-NMMA and L-arginine. Superfusion with 1 microM L-NMMA caused a decrease in Lp (Ltestp/Lcontrolp = 0.6 +/- 0.1, P < 0.001), whereas 1 microM D-NMMA was without effect on Lp (Ltestp/Lcontrolp = 1.0 +/- 0.2). The decrease in Lp by 1 microM L-NMMA was not only prevented by the presence of excess L-arginine (100 microM), but Lp increased fr...Continue Reading

Citations

Dec 17, 2014·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·John A DonaldMelissa S Cameron
Sep 30, 2016·American Journal of Physiology. Renal Physiology·Julia DolininaBengt Rippe
May 30, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Sarah Y Yuan
Aug 12, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Dan PredescuAsrar B Malik
Aug 30, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Brett L Jennings, John A Donald
Jan 15, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Brett L Jennings, John A Donald
Jan 17, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tyler S NelsonJ Brandon Dixon
Sep 28, 2000·Journal of Applied Physiology·J G WoodN C Gonzalez
Dec 12, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Xiao LuGhassan S Kassab
Jun 1, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jun FengWilliam C Aird
Jul 5, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Min-ho KimJohn M Tarbell
Aug 23, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Min-ho KimJohn M Tarbell
Apr 22, 2015·Physiological Reports·Donna A Williams, Mary H Flood
Sep 29, 2000·American Journal of Physiology. Heart and Circulatory Physiology·R E RumbautV H Huxley
Mar 11, 2004·The Journal of Experimental Biology·Brett L JenningsJohn A Donald
Dec 16, 2006·The Journal of Experimental Biology·Brad R S Broughton, John A Donald
Sep 24, 2021·Journal of Applied Physiology·Micha Sam Brickman RaredonLaura E Niklason

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