Capillary lesions develop in retina rather than cerebral cortex in diabetes and experimental galactosemia

Archives of Ophthalmology
T S Kern, R L Engerman

Abstract

To isolate microvessels from cerebral cortex of dogs with alloxan-induced diabetes and dogs with experimental galactosemia to compare the prevalence of microvascular lesions in cerebral cortex with that in retina. Microvessels were isolated from cerebral cortex of experimental animals using a sieving method, and compared with the retinal vasculature isolated from the same animals using the trypsin digestion method. Dogs with diabetes or experimental galactosemia of 5 years' duration had retinopathy that was morphologically indistinguishable from that of humans with diabetes, including microaneurysms, acellular capillaries, and pericyte ghosts. These lesions never were seen in cerebral cortical vessels of the same animals. The only morphologic abnormality observed in cerebral capillaries of dogs with diabetes and dogs fed galactose was thickening of basement membrane. Local influences in the eye apparently play an important role in the development of diabetic retinopathy. Current hypotheses about the pathogenesis of the retinopathy do not account adequately for such differences in the tissue distribution of vascular lesions.

Citations

May 7, 2013·Clinical Lipidology·Julia V BusikGavin E Reid
Nov 29, 2013·Journal of Diabetes Research·Angela Ka Wai Lai, Amy C Y Lo
Jun 1, 2005·The British Journal of Ophthalmology·G B ArdenR O Schlingemann
Jun 26, 2012·Disease Models & Mechanisms·Remya RobinsonTimothy S Kern
Jun 18, 1998·Australian and New Zealand Journal of Ophthalmology·V A AlderP Yu
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Clarisa M BucknerJoan W Berman
Feb 4, 2012·Documenta Ophthalmologica. Advances in Ophthalmology·G B Arden, S Sivaprasad
Sep 13, 2002·Expert Opinion on Investigational Drugs·Alan W StittMark E Cooper
Dec 15, 2015·Eye·S Sivaprasad, G Arden
Apr 4, 2015·Current Eye Research·Xiaoyan JiangYan Luo
Feb 3, 2016·Archivos de la Sociedad Española de Oftalmología·R AlemánI Castaño
Feb 8, 2011·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Yoshimasa NiiyaMasayoshi Takeuchi
Jan 11, 2005·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·G A LammieM W J Strachan
Jun 11, 2002·Biochemical and Biophysical Research Communications·Talitha T Rajah, Paula Grammas
Jun 23, 2004·Neurobiology of Disease·Praveen BallabhMaiken Nedergaard
Jul 30, 2015·Journal of Diabetes Investigation·Timothy S Kern, Bruce A Berkowitz
May 23, 2012·Progress in Retinal and Eye Research·Jane Yellowlees DouglasMaria B Grant
Jul 12, 2016·The Journal of Clinical Investigation·Khalil MiloudiPrzemyslaw Sapieha
Jan 23, 2017·Progress in Retinal and Eye Research·Robert A Linsenmeier, Hao F Zhang
Jun 24, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·S LoukovaaraR J Kaaja
Sep 30, 1998·Journal of Neuroscience Research·R Balabanov, P Dore-Duffy
Oct 7, 1997·Clinical and Experimental Pharmacology & Physiology·V A AlderP K Yu
Apr 18, 2019·Investigative Ophthalmology & Visual Science·Haitao LiuTimothy S Kern
Jul 1, 1995·Diabetes/metabolism Reviews·R L Engerman, T S Kern
Oct 13, 2011·American Journal of Physiology. Endocrinology and Metabolism·Hui WangJin-Ning Lou
Apr 27, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Teruyo KidaTsunehiko Ikeda
May 31, 2018·Investigative Ophthalmology & Visual Science·Rayne R LimShyam S Chaurasia
Sep 12, 2019·Current Diabetes Reports·Avinash HonasogeRithwick Rajagopal
Oct 27, 2001·Microvascular Research·T T RajahP Grammas

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