Capillary microfluidics in microchannels: from microfluidic networks to capillaric circuits

Lab on a Chip
A O OlanrewajuD Juncker

Abstract

Microfluidics offer economy of reagents, rapid liquid delivery, and potential for automation of many reactions, but often require peripheral equipment for flow control. Capillary microfluidics can deliver liquids in a pre-programmed manner without peripheral equipment by exploiting surface tension effects encoded by the geometry and surface chemistry of a microchannel. Here, we review the history and progress of microchannel-based capillary microfluidics spanning over three decades. To both reflect recent experimental and conceptual progress, and distinguish from paper-based capillary microfluidics, we adopt the more recent terminology of capillaric circuits (CCs). We identify three distinct waves of development driven by microfabrication technologies starting with early implementations in industry using machining and lamination, followed by development in the context of micro total analysis systems (μTAS) and lab-on-a-chip devices using cleanroom microfabrication, and finally a third wave that arose with advances in rapid prototyping technologies. We discuss the basic physical laws governing capillary flow, deconstruct CCs into basic circuit elements including capillary pumps, stop valves, trigger valves, retention valves, and...Continue Reading

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Citations

Aug 21, 2019·Micromachines·Anyang WangKwang W Oh
Oct 24, 2019·Lab on a Chip·I Emre AraciAndrew Schmidt
Jan 3, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ahmad Zaman QamarMohtashim Hassan Shamsi
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Jul 3, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yi WeiGuanghui Ma
Sep 9, 2020·Lab on a Chip·Fengyi LiuBo Ma
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May 14, 2021·Lab on a Chip·Mohammad SimchiDavid Sinton
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Nov 10, 2021·Lab on a Chip·Apresio K FajrialXiaoyun Ding

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Methods Mentioned

BETA
chips
electrophoresis
chip
sandwich immunoassay
pregnancy tests
enzyme
Assay
PCR
ELISA

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