Capillary morphogenesis protein 2 is a novel prognostic biomarker and plays oncogenic roles in glioma.

The Journal of Pathology
Juan TanXiu-Wu Bian

Abstract

Capillary morphogenesis protein 2 (CMG2) was originally identified through its participation in capillary morphogenesis, and subsequently identified as the second receptor for anthrax toxin (ANTXR2). Although tumor-associated functions of CMG2 have also been reported, the clinical significance and functional mechanism of CMG2 in glioma remain to be elucidated. We assessed the clinicopathological relevance of CMG2 in a cohort of 48 glioma patients as well as through public glioma databases, and explored the function of CMG2 using glioblastoma (GBM) models in vitro and in vivo. CMG2 overexpression was associated with increased tumor grade and poor patient survival. CMG2 promoted G2/M-phase transition during the cell cycle of GBM cells in vitro and contributed to tumor growth in vivo. We also observed that CMG2 is implicated in the activation of extracellular signal-regulated kinases (ERKs), epithelial-mesenchymal transition (EMT), migration, and invasion in GBM cells. Transcriptomic analysis of GBM cells with or without CMG2 overexpression indicated that a panel of oncogenic signaling pathways was altered with CMG2 upregulation, implying that CMG2 might orchestrate these signaling pathways to regulate the growth of GBM cells. Yes...Continue Reading

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Citations

Nov 22, 2019·Laboratory Investigation; a Journal of Technical Methods and Pathology·Xiang ZhangXiu-Wu Bian
Aug 27, 2019·F1000Research·Oksana A Sergeeva, F Gisou van der Goot
Jan 18, 2020·Laboratory Investigation; a Journal of Technical Methods and Pathology·Xian-Mei WenXiu-Wu Bian
Mar 23, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Liukun MengXiaoyan Liu

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