Capillary morphogenesis protein-2 is required for mouse parturition by maintaining uterine collagen homeostasis.

Biochemical and Biophysical Research Communications
Diane E PetersShihui Liu

Abstract

Capillary morphogenesis protein-2 (CMG2) functions as an anthrax toxin receptor that plays an essential role in anthrax pathogenesis. Although mutations in CMG2 have been identified to cause two human autosomal recessive disorders, Juvenile Hyaline Fibromatosis and Infantile Systemic Hyalinosis, both characterized by excess hyaline material deposition in connective tissues, the physiologic function of CMG2 remains elusive. To study the roles of CMG2 in normal physiology, here we performed detailed histological analyses of the CMG2-null mice we generated previously. While no morphological or histological defects were observed in CMG2(-/-) male mice, CMG2(-/-) female mice were unable to produce any offspring due to a defect in parturition. We found that deletion of CMG2 resulted in a diffuse deposition of collagen within the myometrium of CMG2(-/-) females, causing remarkable morphological changes to their uteri. This collagen accumulation also led to loss of smooth muscle cells in the myometrium of CMG2(-/-) mice, apparently disabling uterine contractile function during parturition. As a consequence, even though pregnant CMG2(-/-) mice were able to carry the gestation to full term, they were unable to deliver pups. However, the ...Continue Reading

References

Sep 1, 1996·Journal of Cellular Physiology·W LeeC A McCulloch
Nov 9, 2001·Nature·K A BradleyJ A Young
Apr 2, 2003·The Journal of Cell Biology·Lars H EngelholmThomas H Bugge
Apr 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Heather M ScobieJohn A T Young
Jul 11, 2007·Molecular and Cellular Biology·Rebecca A Wagenaar-MillerKenn Holmbeck
Jul 21, 2009·Proceedings of the National Academy of Sciences of the United States of America·Shihui LiuStephen H Leppla
Jan 5, 2012·The EMBO Journal·Julie DeuquetF Gisou van der Goot

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Citations

Apr 2, 2014·Trends in Microbiology·Shihui LiuStephen H Leppla
Mar 16, 2016·Toxins·Sarah FriebeJérôme Bürgi
Jun 14, 2014·Biochemical and Biophysical Research Communications·Jianwen ZouBingchang Zhang
Mar 18, 2015·PloS One·Sarah FriebeF Gisou van der Goot
Jun 13, 2017·Nature Communications·Jérôme BürgiF Gisou van der Goot
Aug 27, 2019·F1000Research·Oksana A Sergeeva, F Gisou van der Goot
Jan 13, 2017·American Journal of Hypertension·Xiaoyan LiuJun Cai
Jul 5, 2016·Toxins·Christopher Bachran, Stephen H Leppla
Dec 8, 2017·International Journal of Molecular Sciences·Thomas GreitherMatthias Kappler
Dec 17, 2019·Reproduction in Domestic Animals = Zuchthygiene·Qi WangXingxu Zhao

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