Capillary permeability in rat hindquarters as determined by estimations of capillary reflection coefficients

Acta Physiologica Scandinavica
B Rippe, B Haraldsson

Abstract

Osmotic reflection coefficients (sigma) for a variety of solutes ranging from NaCl to albumin were determined in perfused maximally vasodilated rat hindquarters employing the osmotic transient method (Vargas & Johnson 1964). Measurements were performed at high flows and using short tubings with small volumes. Intracapillary solute concentrations of the osmotic transients were measured or estimated for solutes of the size of inulin or smaller. The PS for Cr-EDTA and cyanocobalamine were determined repeatedly in half of the experiments using an on-line modification of the single injection (indicator diffusion) method (Rippe & Stage 1978) and capillary filtration coefficients (CFC or LpS) were followed in all experiments. The capillary osmotic reflection coefficient was determined to 0.05 for NaCl, to 0.08 for sucrose, to 0.39 for inulin, to 0.57 for myoglobin and to 0.87 for albumin. These reflection coefficients were compatible with a 'small pore radius' of approximately 40 A (slit width (w) of approximately 50 A) according to modern hydrodynamic theories for the reflection coefficient and the parallel transcapillary pathway hypothesis. The best fit of the osmotic transient data to current theories for the reflection coefficient...Continue Reading

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Citations

Apr 5, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Bengt Rippe
Feb 11, 2003·Critical Care Medicine·Staffan Holbeck, Per-Olof Grände
Jul 1, 1986·Acta Physiologica Scandinavica·B Haraldsson, B Rippe
Nov 1, 1993·Acta Physiologica Scandinavica·E R Zakaria, B Rippe
Mar 16, 2005·Skin Pharmacology and Physiology·K Kretsos, G B Kasting
Dec 17, 2002·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Matthew B Wolf
Nov 9, 2006·American Journal of Physiology. Renal Physiology·Bengt Rippe, Daniele Venturoli
Jul 12, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·M F Flessner
Jul 3, 1999·Physiological Reviews·C C Michel, F E Curry
Apr 19, 2017·The Journal of Physiological Sciences : JPS·Akitoshi MaedaAkira Amano
May 10, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Michael R Kellen, James B Bassingthwaighte

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