Capillary remodeling in infants born to hypertensive pregnancy: pilot study

American Journal of Hypertension
Tarek F AntoniosIsaac T Manyonda

Abstract

Capillary rarefaction is pathognomonic of essential hypertension. We have previously shown significant capillary rarefaction in normotensive adult offspring of hypertensive parents, suggesting a familial predisposition in which capillary rarefaction represents a primary vascular abnormality that antedates the onset of sustained elevation of blood pressure (BP). We have recently reported that low-birth weight (LBW) infants, born at term or preterm, to normotensive mothers do not have capillary rarefaction at birth. We hypothesized that infants born to mothers with hypertensive disorders of pregnancy (HDP) would have significant capillary rarefaction at birth when compared to infants of normotensive mothers. We studied 22 infants born to hypertensive mothers and compared them to 40 normal birth weight infants born at term to normotensive mothers. We used orthogonal polarized spectroscopy to measure basal (i.e., functional) and maximal (i.e., structural) skin capillary densities according to a well-validated protocol. We found that term infants born to hypertensive mothers had significantly lower maximal capillary density (MCD) (mean difference of -5.0 capillaries/mm(2); P < 0.05). However, preterm infants with LBW born to hyperte...Continue Reading

References

Oct 1, 1991·British Journal of Obstetrics and Gynaecology·D S SeidmanY L Danon
Sep 9, 1989·Lancet·D J BarkerS J Simmonds
Jan 15, 1988·Klinische Wochenschrift·H A HenrichF Bäumer
Sep 1, 1993·Acta Paediatrica. Supplement·D J Barker
Jan 10, 2003·The New England Journal of Medicine·Gunhild KellerKerstin Amann
May 2, 2006·American Journal of Hypertension·Tarek Francis Antonios
Aug 30, 2008·Circulation·Bernard I LevyHarry A J Struijker-Boudier
Mar 7, 2009·Stroke; a Journal of Cerebral Circulation·Eero KajantieDavid J P Barker
Jun 2, 2009·American Journal of Respiratory and Critical Care Medicine·Christopher D BakerVivek Balasubramaniam
Jul 18, 2009·Journal of Hypertension·Bjørn ØglaendLars J Vatten
Oct 5, 2011·Hypertension·Harry A J Struijker-Boudier, Bart F J Heijnen

❮ Previous
Next ❯

Citations

Dec 24, 2014·International Journal of Molecular Sciences·Marius C StaiculescuLuis A Martinez-Lemus
Jun 14, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Liesbeth ThewissenPetra Lemmers
Jul 13, 2013·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Rajendra P RaghuramanTarek F T Antonios
May 29, 2018·Expert Opinion on Drug Metabolism & Toxicology·Paul Malik, Andrea Edginton
Dec 21, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Kalliopi KaratziSebastien Czernichow
Apr 4, 2015·Current Hypertension Reports·Areti TriantafyllouStella Douma
May 1, 2020·Journal of the American Heart Association·Christina Y L AyePaul Leeson
Jul 17, 2015·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Vanina S Kanoore EdulArnaldo Dubin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.