Capillary separation: micellar electrokinetic chromatography

Annual Review of Analytical Chemistry
S Terabe

Abstract

Micellar electrokinetic chromatography (MEKC), a separation mode of capillary electrophoresis (CE), has enabled the separation of electrically neutral analytes. MEKC can be performed by adding an ionic micelle to the running solution of CE without modifying the instrument. Its separation principle is based on the differential migration of the ionic micelles and the bulk running buffer under electrophoresis conditions and on the interaction between the analyte and the micelle. Hence, MEKC's separation principle is similar to that of chromatography. MEKC is a useful technique particularly for the separation of small molecules, both neutral and charged, and yields high-efficiency separation in a short time with minimum amounts of sample and reagents. To improve the concentration sensitivity of detection, several on-line sample preconcentration techniques such as sweeping have been developed.

References

Oct 1, 1992·Journal of Pharmaceutical and Biomedical Analysis·S Terabe
Dec 1, 1967·Chromatographic Reviews·S Hjertén
Feb 23, 1996·Journal of Chromatography. B, Biomedical Applications·J OravcováW Lindner
Oct 25, 2000·Journal of Chromatography. a·K D Altria
Nov 7, 2001·Journal of Chromatography. a·J B KimS Terabe
Dec 14, 2002·Electrophoresis·Manuel Molina, Manuel Silva
Dec 18, 2002·Journal of Pharmaceutical and Biomedical Analysis·Jong-Bok Kim, Shigeru Terabe
Dec 9, 2003·Electrophoresis·Steen Honoré Hansen
Jul 13, 2004·Analytical Chemistry·Shigeru Terabe
Feb 17, 2005·Electrophoresis·Theron J PappasLisa A Holland
Nov 30, 2005·Electrophoresis·Christian Nilsson, Staffan Nilsson
Nov 30, 2005·Electrophoresis·Christian Schou, Niels H H Heegaard
Nov 30, 2005·Electrophoresis·Carmen W Huie
Dec 1, 2006·Electrophoresis·Eamon McEvoyJoe Power
Dec 1, 2006·Electrophoresis·Manuel Silva
Nov 24, 2007·Journal of Chromatography. a·Steven L SimpsonShigeru Terabe
Jan 22, 2008·Journal of Chromatography. a·Salwa K Poole, Colin F Poole
Aug 2, 2008·Analytical Chemistry·Joselito P Quirino, Paul R Haddad

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Citations

Jan 16, 2014·Interface Focus·Larry R Gibson, Paul W Bohn
Jan 22, 2014·Analytical Biochemistry·Andrew MalinaS Douglass Gilman
Aug 22, 2012·Journal of Pharmaceutical and Biomedical Analysis·Iuliana OitaYvan Vander Heyden
Aug 20, 2010·Journal of Pharmaceutical and Biomedical Analysis·Alexandre Zatkovskis CarvalhoAnn Van Schepdael
May 16, 2014·Biomedical Chromatography : BMC·Ewelina SieradzkaHalina Milnerowicz
Apr 5, 2015·Journal of Pharmaceutical and Biomedical Analysis·Nantana NuchtavornLeena Suntornsuk
May 24, 2015·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Hamid Babamoradi, Hamid Abdollahi
May 3, 2016·Journal of Pharmaceutical and Biomedical Analysis·Lei LiuHua Yang
Aug 9, 2016·Analytica Chimica Acta·Sille Štěpánová, Václav Kašička
Jul 9, 2013·Journal of Chromatographic Science·Yi HuangHang Song
Dec 1, 2011·Electrophoresis·Petr Kubáň, Andrei R Timerbaev
Nov 26, 2009·Journal of Separation Science·Diana L D LimaValdemar I Esteves
Dec 2, 2009·Electrophoresis·Václav Kasicka
Dec 21, 2010·Electrophoresis·Zdena MaláPetr Boček
May 20, 2014·Journal of Separation Science·Sille Stěpánová, Václav Kašička
Dec 6, 2011·Electrophoresis·Václav Kašička
Dec 8, 2011·Electrophoresis·Heide R RabanesJoselito P Quirino
Apr 19, 2011·Electrophoresis·Christian NilssonStaffan Nilsson
Nov 28, 2012·Proteomics·Pier Giorgio RighettiAttilio Citterio
Apr 21, 2020·Journal of Dairy Science·Jaroslava BezdekovaMarketa Vaculovicova
Aug 17, 2020·Journal of Chromatography. a·Sandra Salido-FortunaMaría Luisa Marina
Feb 4, 2021·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Takashi Ito, Daniel A Higgins
May 4, 2011·Journal of Chromatography. a·Pier Giorgio Righetti, Giovanni Candiano

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Methods Mentioned

BETA
electrophoresis

Software Mentioned

SDS

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