PMID: 8964755Mar 1, 1996Paper

Capillary-to-fiber surface ratio in rat fast-twitch hindlimb muscles after chronic electrical stimulation

Journal of Applied Physiology
O Mathieu-CostelloT H Adair

Abstract

We examined the relative plasticity of capillaries and fiber mitochondria in rat fast-twitch hindlimb muscles in response to chronic electrical stimulation. Specifically we addressed whether the size of the capillary-fiber interface increases in proportion to fiber mitochondrial volume, inasmuch as fiber aerobic capacity increases severalfold with chronic stimulation. Tibialis anterior and extensor digitorum longus muscles of six rats [367 +/- 17 (SD) g body wt] were stimulated (10 Hz, 8 h/day, 7 days/wk) for 28 consecutive days. Subsequently they were perfusion fixed in situ and stimulated, and contralateral control samples from the midbelly were processed for electron microscopy and morphometry. Capillary length density, capillary-to-fiber ratio, and fiber mitochondrial volume density increased two- to threefold in stimulated muscles, with no change in fiber or capillary diameter. Capillary-to-fiber surface area ratio per fiber unit mitochondrial volume was unchanged in stimulated muscles compared with contralateral controls, indicating a proportional increase in the size of the capillary-fiber interface and fiber mitochondrial volume in the muscles after chronic electrical stimulation.

Citations

Oct 20, 2001·Journal of Applied Physiology·R T Hepple, O Mathieu-Costello
May 7, 2002·Exercise and Sport Sciences Reviews·Odile Mathieu-Costello, Russell T Hepple
Sep 18, 2002·Journal of Applied Physiology·Kyle K HendersonNorberto C Gonzalez
Oct 9, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Muharrem InanSaim Yologlu
Sep 15, 2005·Cell and Tissue Research·Vita CebasekIda Erzen
Dec 27, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Petr DobsákKou Imachi
Mar 17, 2009·Journal of Applied Physiology·Lisa E WongRussell T Hepple
Aug 29, 2017·Medicine and Science in Sports and Exercise·Tanya M HollowayLex B Verdijk
Feb 1, 1997·Journal of Applied Physiology·D C Poole, O Mathieu-Costello
Mar 19, 2005·Journal of Applied Physiology·O Mathieu-CostelloL Cui
Oct 30, 2001·High Altitude Medicine & Biology·O Mathieu-Costello
Jul 28, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Iman MomkenVladimir Veksler
Oct 22, 2010·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Howard J GreenSusan Tupling
Apr 5, 2012·Canadian Journal of Physiology and Pharmacology·Howard J GreenSusan Tupling
Jun 19, 2002·Journal of Applied Physiology·O Mathieu-CostelloM Vornanen
Dec 14, 2004·Journal of Applied Physiology·Hidemi FujinoFumihiko Kajiya
Oct 30, 2007·Nature Neuroscience·Costantino Iadecola, Maiken Nedergaard
Feb 5, 2000·Journal of Applied Physiology·R T HeppleP D Wagner
Mar 3, 2004·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·Bart E DrinkardLisa G Rider
Jul 16, 2008·Archives of Histology and Cytology·Emiko IchinoseSeiichi Kawamata
Nov 6, 1998·Journal of Applied Physiology·R T HeppleO Mathieu-Costello
Jul 13, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·P D WagnerJ Roca

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