PMID: 6985647Jan 1, 1980Paper

Capping and adenosine metabolism. Genetic and pharmacologic studies

The Journal of Experimental Medicine
J BraunE R Unanue

Abstract

Capping of membrane Ig was studied in lymphocytes treated with agents that interfere with adenosine metabolism. Treatment of murine or human B cells with combinations of coformycin, an inhibitor of adenosine deaminase, homocysteine, and adenosine impaired Ig capping. Inhibition of capping was also produced by 3-deazaadenosine, a specific inhibitor of adenosylhomocysteine hydrolase. The inhibitors did not affect capping of the Thy-1 antigen or membrane sites reactive with antilymphocyte antibodies. Two patients with a hereditary deficiency in adenosine deaminase had impairment of Ig capping. Such an impairment was not found in lymphocytes of two other patients who had undergone successful bone marrow transplantation. It is known that the addition of a calcium ionophore results in activation of microfilament function and in disruption of Ig caps. The ionophore effect was not inhibited by the agents mentioned above. Our results suggest that the inhibition of Ig capping during aberrant adenosine metabolism may be caused by a methylation defect preceding the contracticle event that produces membrane reorganization.

References

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Citations

Jul 1, 1981·Molecular and Cellular Biochemistry·D L DoggettB L Strehler
Jun 10, 1985·Biochimica Et Biophysica Acta·I Y KimP K Chiang
Jan 1, 1986·International Journal of Immunopharmacology·D BrohéeP Nève
Jan 1, 1987·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·A van Waarde
May 13, 1998·Pharmacology & Therapeutics·P K Chiang
Oct 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·T P ZimmermanG B Elion
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R W KunclR Adams
Dec 1, 1981·The Journal of Cell Biology·J M OliverR D Berlin
Feb 1, 1983·Clinical Biochemistry·B J Zegers, J W Stoop
Jan 1, 1980·Immunological Reviews·J Braun, E R Unanue
Jan 1, 1983·Immunology Today·J Braun
Jan 1, 1985·Annals of the New York Academy of Sciences·M C Pike, R Snyderman
Jul 29, 1983·Biochemical and Biophysical Research Communications·R K GordonP K Chiang
Aug 15, 1984·Analytical Biochemistry·G A MiuraP K Chiang

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