CAPRICORN: a story of alpha allocation and beta-blockers in left ventricular dysfunction post-MI

International Journal of Cardiology
A J Coats

Abstract

Beta-blocker therapy is beneficial both after myocardial infarction and in mild, moderate and severe chronic heart failure. Recent sub-group analysis of the Goteborg Metoprolol Trial and the AIRE study confirm that patients receiving beta-blockers in the setting of post-MI heart failure fare better than patients not receiving this therapy. For all these reasons the CAPRICORN trial of carvedilol in post-MI LV dysfunction was an important and eagerly awaited trial. The results were presented for the first time at The American College of Cardiology on March 20 2001. CAPRICORN randomised 984 patients to placebo and 975 to carvedilol between 3 and 21 days (mean 10) after a confirmed MI. Patients had to have evidence of a left ventricular ejection fraction 40% or less. All patients had received ACEI therapy for at least 48 hours prior to randomisation. The mean ejection fraction of the patients recruited was 32.7% in the placebo group and 32.9% in the carvedilol group. Follow-up was for a mean of 15 months (maximum 2.7 years). All cause mortality was 15.3% (151 deaths) in the placebo group and 11.9% (116 deaths) in the carvedilol group, giving a hazard ratio of 0.77 (0.60-0.98) and a significance of p = 0.031. And yet this agent will...Continue Reading

References

May 1, 1994·Journal of the American College of Cardiology·B AnderssonF Waagstein
Jan 27, 1999·Clinical Science·J E SandersonL Bernardi
Apr 3, 1999·International Journal of Cardiology·H TygesenB Wennerblom
Apr 23, 1999·European Heart Journal·M R CowieG C Sutton
Nov 26, 1999·International Journal of Cardiology·A J Coats
Apr 5, 2000·International Journal of Cardiology·A C TeismanW H van Gilst
Apr 5, 2000·International Journal of Cardiology·K MatsuyamaT Yoshioka
May 19, 2000·International Journal of Cardiology·A J Coats
Jun 8, 2000·International Journal of Cardiology·A J Coats
Oct 31, 2000·International Journal of Cardiology·A J Coats
Oct 31, 2000·International Journal of Cardiology·K J HarjaiJ Newman
Nov 4, 2000·Journal of Cardiovascular Electrophysiology·D Aronson, A J Burger
Nov 15, 2000·International Journal of Cardiology·A J Coats
Dec 29, 2000·Journal of the American College of Cardiology·B A GroenningP R Hildebrandt

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Citations

Nov 19, 2010·Trials·Benjamin FrenchUNKNOWN COAG (Clarification of Optimal Anticoagulation through Genetics) Investigators
Feb 10, 2017·Clinical Trials : Journal of the Society for Clinical Trials·Bruce W Turnbull
Jan 15, 2004·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Robert Hemmings, Simon Day
Dec 18, 2019·The Cochrane Database of Systematic Reviews·Sanam SafiChristian Gluud
Jun 7, 2019·Nature Reviews. Disease Primers·Birgit VogelRoxana Mehran

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