Caprine PRNP polymorphisms at codons 171, 211, 222 and 240 in a Greek herd and their association with classical scrapie

The Journal of General Virology
Ilias G BouzalasGeorgios Koptopoulos

Abstract

The association between PRNP variation and scrapie incidence was investigated in a highly affected Greek goat herd. Four mutations were identified at codons 171Q/R, 211R/Q, 222Q/K and 240P/S. Lysine at codon 222 was found to be associated with the protection from natural scrapie (P=0.0111). Glutamine at codon 211 was observed in eight animals, all of them being scrapie-negative, indicating a possible protective role of this polymorphism although statistical analysis failed to support it (P=0.1074). A positive association (P=0.0457) between scrapie-affected goats and the wild-type Q(171)R(211)Q(222)S(240) allele is presented for the first time. In addition, a novel R(171)RQS allele, which is identical to the A(136)R(154)R(171) allele that has been associated with resistance to classical scrapie in sheep, was observed in low frequency. Resistant alleles that include K(222) and Q(211) are absent or rare in sheep and can provide the basis for the development of a feasible breeding programme for scrapie eradication in goats.

References

Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·G C TellingS B Prusiner
Jan 1, 1994·Annual Review of Neuroscience·S B Prusiner, S J DeArmond
May 1, 1996·Journal of Clinical Microbiology·L J van KeulenJ P Langeveld
Oct 1, 1996·The Journal of General Virology·A BossersM A Smits
Aug 9, 1997·The Veterinary Record·N HunterG Smith
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·S B Prusiner
Feb 14, 2002·The Journal of General Virology·Charalambos BillinisTheodoros Sklaviadis
Nov 30, 2004·Animal Genetics·L ZhangW Xu
Apr 19, 2005·The Veterinary Record·David M McDowell
Mar 11, 2006·The Journal of General Virology·P L AcutisM Caramelli
Apr 11, 2006·The Journal of General Virology·Gabriele VaccariUmberto Agrimi
Apr 27, 2007·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Torsten SeuberlichAndreas Zurbriggen
Nov 15, 2008·The Journal of General Virology·Silvia ColussiPier Luigi Acutis

❮ Previous
Next ❯

Citations

Dec 25, 2012·Biochemical Genetics·Rongyan ZhouZhujun Zhao
Apr 1, 2011·Journal of Clinical Microbiology·Ilias G BouzalasTorsten Seuberlich
Dec 20, 2012·Veterinary Research·Sylvie L BenestadIngrid Olsaker
Feb 3, 2011·BMC Veterinary Research·Katherine I O'RourkeDavid A Schneider
Jan 28, 2014·PloS One·Gwenola Tosser-KloppUNKNOWN International Goat Genome Consortium
Feb 13, 2016·The Veterinary Record·Cristina Acín, José Luis Pitarch
Mar 19, 2016·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·J J WindigJ P M Langeveld
Oct 27, 2012·The Journal of General Virology·Fabien CorbièreOlivier Andreoletti
Dec 3, 2014·Virus Research·Patricia Aguilar-CalvoJuan María Torres
Jun 4, 2015·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Sally A Madsen-BouterseKatherine I O'Rourke
Aug 24, 2012·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Maria MazzaPier Luigi Acutis
Nov 23, 2010·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Torsten SeuberlichAndreas Zurbriggen
Apr 19, 2018·The Veterinary Record·Yong-Chan Kim, Byung-Hoon Jeong
Dec 20, 2013·Journal of Virology·Patricia Aguilar-CalvoJuan María Torres
Oct 21, 2019·Tropical Animal Health and Production·Iraz AkisCemal Un
May 20, 2020·Animal Biotechnology·Manaswini MandalGangadhar Nayak
Jul 5, 2017·Journal of Genetics·Hasan MeydanWilfred Goldmann
Jan 12, 2020·Veterinary Research·Øyvind SalvesenCecilie Ersdal
Aug 10, 2017·EFSA Journal·UNKNOWN EFSA Panel on Biological Hazards (BIOHAZ)Emma Snary
Oct 20, 2020·Frontiers in Bioengineering and Biotechnology·Christopher J SilvaIrina C Dynin
Feb 3, 2021·Animals : an Open Access Journal From MDPI·Martina TorricelliMassimo Biagetti
Nov 3, 2020·Frontiers in Veterinary Science·Sergio MiglioreGuido Ruggero Loria
Jun 3, 2021·Animals : an Open Access Journal From MDPI·Samia KdidiGabriele Vaccari
Jun 21, 2021·Genetics, Selection, Evolution : GSE·Sally A Madsen-BouterseWilfred Goldmann
Aug 28, 2021·Animals : an Open Access Journal From MDPI·Athanasios I GelasakisLoukia V Ekateriniadou

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.