Capsaicin 8% dermal patch in clinical practice: an expert opinion

Expert Opinion on Pharmacotherapy
Cesare BonezziAnthony H Dickenson

Abstract

Neuropathic pain (NP) is caused by a lesion or disease of the somatosensory system, which can severely impact patients' quality of life. The current-approved treatments for NP comprise of both centrally acting agents and topical drugs, including capsaicin 8% dermal patches, which is approved for the treatment of peripheral NP. The authors summarize literature data regarding capsaicin use in patients who suffer from NP and discuss the clinical applications of this topical approach. Overall, the capsaicin 8% dermal patch is as effective in reducing pain intensity as other centrally active agents (i.e. pregabalin). Some studies have also reported fewer systemic side effects, a faster onset of action and superior treatment satisfaction compared with systemic agents. In our opinion, capsaicin 8% dermal patches also present additional advantages, such as a good systemic tolerability, the scarcity of adverse events, the possibility to combine it with other agents, and a good cost-effective profile. It is important to note that, as the mechanism of action of capsaicin 8% is the 'defunctionalization' of small afferent fibers through interaction with TRPV1 receptors, the peripheral expression of this receptor on nociceptor fibers, is cru...Continue Reading

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Citations

Sep 13, 2020·Journal of Diabetes Investigation·Dan ZieglerChaicharn Deerochanawong
Nov 10, 2020·Drugs·Mircea IftincaChristophe Altier
Feb 14, 2021·European Journal of Medicinal Chemistry·Dong-Jun FuBin Yu
Nov 13, 2020·Pharmacology & Therapeutics·Vipin AroraMan-Kyo Chung
Sep 17, 2021·Nature Reviews. Drug Discovery·Ari-Pekka KoivistoArpad Szallasi

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