PMID: 8947063Nov 1, 1996Paper

Capsaicin cough receptor sensitivity test in children

The European Respiratory Journal
A B ChangC F Robertson

Abstract

Capsaicin has been used as a tussive agent in studies in adults to determine cough receptor sensitivity. The aim of this study was to determine the tolerance, repeatability and influence of inspiratory flow on the capsaicin cough receptor sensitivity test in children. Thirty children (mean age 11 yrs; range 6-16 yrs) were tested on two different days, to determine the lowest concentration of capsaicin required to stimulate two or more coughs (cough threshold (Cth)), 2-4 coughs (C2), and five or more coughs (C5). Capsaicin was nebulized through a dosimeter, with an arrangement that allowed the subjects to visualize and regulate their inspiratory flow. Using a constant inspiratory flow of 20 L x min(-1), tests were reproducible for C2, C5 and Cth (doubling dose changes of 1.13, 1.03 and 1.08, respectively). An increase in the inspiratory flow from 20 to 60 L x min(-1) significantly increased C2 (19.5 to 46.8 microM; p=0.016) and C5 (46.8 to 128.8 microM; p=0.008). We conclude that in children, the capsaicin cough challenge test: 1) is well-tolerated; 2) is highly repeatable; and that 3) the inspiratory flow significantly influences cough receptor sensitivity and repeatability of the test and should, thus, be regulated.

Citations

Dec 6, 1997·Archives of Disease in Childhood·A B ChangC F Robertson
Oct 15, 1998·Archives of Disease in Childhood·A B ChangC F Robertson
Mar 29, 2002·Archives of Disease in Childhood·A B ChangP G Gibson
Dec 24, 2002·Archives of Disease in Childhood·A B ChangS M Sawyer
Dec 3, 2005·American Journal of Respiratory and Critical Care Medicine·Danny J EckertR Doug McEvoy
Nov 8, 2005·Cough·Anne B Chang
May 15, 2013·Cough·Alyn H Morice
Jul 14, 2010·European Journal of Medical Research·M CiljakovaP Banovcin
Mar 12, 2011·Chest·Anne B ChangColin F Robertson
Jun 27, 2014·Chest·Michelle S TrocheKaren W Hegland
Jul 9, 2005·Chest·Peter V Dicpinigaitis, Rakesh V Alva
Feb 12, 2005·Chest·Benjamin PrudonIan D Pavord
Feb 23, 2010·Otolaryngologic Clinics of North America·Anne B Chang, Robert G Berkowitz
Feb 15, 2015·Pulmonary Pharmacology & Therapeutics·Surinder S BirringAnne B Chang
Nov 23, 2006·Pulmonary Pharmacology & Therapeutics·Anne B Chang, John G Widdicombe
Nov 15, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·N JavorkovaM Kollarik
Jul 9, 2002·Pulmonary Pharmacology & Therapeutics·R W Fuller
Jul 9, 2002·Pulmonary Pharmacology & Therapeutics·Anne B Chang, Peter G Gibson
Apr 16, 2003·Respiratory Medicine·L NietoJ Ponce
Oct 20, 2005·The Cochrane Database of Systematic Reviews·A A T TomerakM C McKean
Jul 22, 2005·The Cochrane Database of Systematic Reviews·A A T TomerakM McKean
Jul 21, 2004·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Anne B ChangMelissa Hubbard

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.