PMID: 7536950Jan 5, 1995Paper

Capsaicin effects on substance P and CGRP in rat adjuvant arthritis

Regulatory Peptides
M AhmedA Kreicbergs

Abstract

The effects of capsaicin on the sensory neuropeptides substance P and calcitonin gene-related peptide were analyzed in the ankle joints and dorsal root ganglia (L2-L6) of adult female Lewis rats. The study included 23 normal rats and 23 arthritic rats, all injected subcutaneously with capsaicin (total dose 200 mg/kg bw). Another two groups of animals from a previous study, i.e., 23 normal rats and 23 arthritic rats not given capsaicin served as controls. Adjuvant arthritis was induced by inoculation with heat-killed mycobacteria. The morphological distribution of sensory neuropeptides was assessed by immunohistochemistry and the tissue concentrations were determined by radioimmunoassay. In normal rats, capsaicin significantly reduced the concentrations of substance P and calcitonin gene-related peptide in ankle joints (54 and 36%, respectively) as well as dorsal root ganglia (40 and 54%, respectively). In arthritic rats those pretreated with capsaicin had significantly lower concentrations of substance P and calcitonin gene-related peptide in dorsal root ganglia (19 and 42%, respectively) compared to the arthritic controls. In the ankle joints, however, only the SP concentration was reduced (42%). Notably, this was accompanied ...Continue Reading

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Citations

Feb 14, 1998·Archives of Oral Biology·J CarlesonT Lundeberg
Feb 1, 2002·European Journal of Pharmacology·Mariana SpeteaAndris Kreicbergs
Jul 11, 1997·Neuroscience Letters·N E GarrettD R Tomlinson
Mar 7, 2002·Journal of Neuroimmunology·Luisa Bracci-LaudieroThomas Lundeberg
Jan 30, 2014·Drug Delivery·Khomendra Kumar SarwaVinod Kumar Verma
Jan 27, 2016·Autoimmunity Reviews·Yaxiong DengYehuda Shoenfeld
Jan 27, 2012·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Daniel K I BringPaul W Ackermann
Jun 20, 2015·Nature Reviews. Neuroscience·Stephen B McMahonDavid L H Bennett
Jun 3, 2016·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Éva BorbélyZsuzsanna Helyes
Apr 14, 2017·Nature Reviews. Rheumatology·Shani DahanYehuda Shoenfeld
Oct 8, 2014·Physiological Reviews·F A RussellS D Brain
Mar 22, 2020·Animals : an Open Access Journal From MDPI·Anne Franck Gallagher Vom BrauckeCasper Lindegaard
Dec 22, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·E Gouze-DecarisB Terlain

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