Capsaicin for allergic rhinitis in adults.

The Cochrane Database of Systematic Reviews
J ChengS P Zhang

Abstract

Allergic rhinitis represents a global health problem. Non-specific nasal hyperresponsiveness is an important feature of allergic and non-allergic rhinitis. This phenomenon is believed to result from the effect of allergic inflammation on the sensory nerves that supply the upper airway mucosa. A pharmacologic agent that has proved useful in the investigation of effects of neuronal stimulation is capsaicin, the pungent component of hot pepper. Intranasal capsaicin specifically stimulates afferent nerves consisting mostly of unmyelinated C fibers and some myelinated A-delta fibers. As a result it can trigger central and axonal reflexes, the latter being putatively mediated by the release of neuropeptides. Capsaicin as a blocking agent of neuropeptides, blocks the axon reflex and may exert a curative effect on allergic rhinitis. To assess the effectiveness of capsaicin for allergic rhinitis in adults. We searched the Cochrane Ear, Nose and Throat Disorders Group Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library Issue 1, 2006), MEDLINE (1966 to 2006) and EMBASE (1974 to 2006). We assessed bibliographies from included studies, and contacted authors of known studies for additional...Continue Reading

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Citations

Oct 24, 2012·Chemical Research in Toxicology·Christopher A ReillyGarold S Yost
Jul 15, 2015·The Cochrane Database of Systematic Reviews·Artur GevorgyanWytske Fokkens
Nov 3, 2010·Physiotherapy Theory and Practice·Rebecca MarshallLes Wood
Jan 1, 2011·Revista brasileira de hematologia e hemoterapia·Marcia Cristina Zago Novaretti, Carla Luana Dinardo
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