Abstract
Allergic rhinitis represents a global health problem. Non-specific nasal hyperresponsiveness is an important feature of allergic and non-allergic rhinitis. This phenomenon is believed to result from the effect of allergic inflammation on the sensory nerves that supply the upper airway mucosa. A pharmacologic agent that has proved useful in the investigation of effects of neuronal stimulation is capsaicin, the pungent component of hot pepper. Intranasal capsaicin specifically stimulates afferent nerves consisting mostly of unmyelinated C fibers and some myelinated A-delta fibers. As a result it can trigger central and axonal reflexes, the latter being putatively mediated by the release of neuropeptides. Capsaicin as a blocking agent of neuropeptides, blocks the axon reflex and may exert a curative effect on allergic rhinitis. To assess the effectiveness of capsaicin for allergic rhinitis in adults. We searched the Cochrane Ear, Nose and Throat Disorders Group Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library Issue 1, 2006), MEDLINE (1966 to 2006) and EMBASE (1974 to 2006). We assessed bibliographies from included studies, and contacted authors of known studies for additional...Continue Reading
References
Sep 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J S LacroixJ M Lundberg
Nov 1, 1988·The Journal of Allergy and Clinical Immunology·B LebelF B Michel
Dec 1, 1995·The Journal of Allergy and Clinical Immunology·G CiprandiG W Canonica
Feb 1, 1996·Controlled Clinical Trials·A R JadadH J McQuay
Apr 1, 1996·Allergy·N AbergB Aberg
Dec 6, 1997·The Journal of Allergy and Clinical Immunology·A M SanicoA Togias
Feb 26, 1998·Journal of Applied Physiology·A M SanicoA Togias
Apr 16, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A M SanicoA Togias
May 16, 1998·Acta Oto-laryngologica·P StjärneA Anggård
Jan 12, 2000·The Journal of Allergy and Clinical Immunology·V RiccaG Ciprandi
Jun 16, 2000·The Journal of Allergy and Clinical Immunology·A Togias
Dec 21, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R Gerth Van WijkS Popering
Jul 13, 2001·The Journal of Allergy and Clinical Immunology·D P Skoner
Sep 14, 2001·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·B J FergusonE Rubinstein
Nov 15, 2001·The Journal of Allergy and Clinical Immunology·J BousquetUNKNOWN World Health Organization
Mar 26, 2008·Allergy·J BousquetUNKNOWN AllerGen
Nov 18, 2008·Acta Oto-laryngologica·Pier Guido Ciabatti, Luca D'Ascanio
Citations
Oct 24, 2012·Chemical Research in Toxicology·Christopher A ReillyGarold S Yost
Jul 15, 2015·The Cochrane Database of Systematic Reviews·Artur GevorgyanWytske Fokkens
Apr 28, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Koen Van CrombruggenC Bachert
Jan 6, 2015·Iranian Red Crescent Medical Journal·Damin CaiXingming Ma
Jul 5, 2017·Journal of Perinatal Medicine·Kyung Joon OhBo Hyun Yoon
Nov 3, 2010·Physiotherapy Theory and Practice·Rebecca MarshallLes Wood
Jan 1, 2011·Revista brasileira de hematologia e hemoterapia·Marcia Cristina Zago Novaretti, Carla Luana Dinardo
Aug 6, 2014·Australian Dental Journal·G AlexanderR H K Wong
Jun 10, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Takashi FujiwaraNaohito Hato
Oct 19, 2021·Frontiers in Medicine·Yu LiuYuedong Hou