Capsaicin-induced activation of pulmonary vagal C fibers produces reflex laryngeal closure in the rat

Journal of Applied Physiology
I-Jung LuJi-Chuu Hwang

Abstract

Our recent studies show that intravenous administration of capsaicin induces enhancement of the intralaryngeal thyroarytenoid (TA) branch but a reduction of the intralaryngeal abducent branch, suggesting that the glottis is likely closed by capsaicin. The aim of the present study was to examine whether the glottis is adducted by intravenous administration of capsaicin. Electromyographic (EMG) activity of the TA muscle, subglottal pressure (SGP), and glottal behavior were evaluated before and after intravenous administration of capsaicin in male Wistar rats that were anesthetized and tracheostomized. Catheters were placed in the femoral artery and vein, as well as in the right jugular vein. Low and high doses of capsaicin (0.625 and 1.25 microg/kg) produced apnea and increases in the amplitude of the TA EMG. This enhancement of the TA EMG was observed during apnea as well as during recovery from apnea. Moreover, the onset of the TA EMG was advanced such that it commenced earlier during inspiration. Concomitantly, the SGP substantially increased. Increases in both the TA EMG and SGP were abolished after bilateral sectioning of the recurrent laryngeal nerve. In some animals, movement of the vocal folds was recorded by taking a mot...Continue Reading

References

Apr 1, 1977·Respiration Physiology·H M Coleridge, J C Coleridge
Mar 1, 1990·Journal of Applied Physiology·L Y LeeY R Kou
May 1, 1990·Journal of Applied Physiology·A TullyL A Engel
Jan 1, 1989·Physiological Reviews·D Bartlett
Sep 1, 1989·Journal of Applied Physiology·D ZhouD Bartlett
Jun 1, 1973·The Journal of Physiology·A StranskyJ G Widdicombe
Aug 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J F GreenJ C Coleridge
Mar 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·S J EnglandJ A Daubenspeck
Jul 1, 1980·Circulation Research·S WallensteinJ L Fleiss
Feb 1, 1994·The Laryngoscope·N M BaumanR J Smith
Feb 1, 1993·Journal of Applied Physiology·G InsalacoG Bonsignore
Feb 6, 1998·Journal of Applied Physiology·C J Lai, Y R Kou
Jul 31, 1998·The Annals of Otology, Rhinology, and Laryngology·N M BaumanA D Sandler
Feb 25, 1999·The Annals of Otology, Rhinology, and Laryngology·N M BaumanE S Luschei
Mar 10, 2001·Respiration Physiology·G Sant'Ambrogio, J Widdicombe
Mar 10, 2001·Respiration Physiology·L Y Lee, T E Pisarri
Aug 16, 2001·Respiration Physiology·C Y HoL Y Lee
Mar 15, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mathias Dutschmann, Julian F R Paton
Jan 14, 2003·Journal of Applied Physiology·Philippe ReixJean-Paul Praud
Mar 11, 2003·Journal of Applied Physiology·Pierre-Hugues FortierJean-Paul Praud
Mar 27, 2003·Pulmonary Pharmacology & Therapeutics·Maria G Belvisi
Nov 13, 2004·The Annals of Otology, Rhinology, and Laryngology·Nancy M Bauman, DeQiang Wang

❮ Previous
Next ❯

Citations

Sep 1, 2012·Journal of Applied Physiology·Kun-Ze LeeJi-Chuu Hwang
Aug 17, 2010·The Journal of the Acoustical Society of America·Aaron M JohnsonNadine P Connor
Jun 27, 2018·Journal of Neurotrauma·Kun-Ze Lee, Ke-Jun Xu
Feb 23, 2021·ERJ Open Research·Richard W ChapmanWalter Perkins

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.