PMID: 8600135Sep 1, 1995Paper

Capsaicin-induced release of substance P increases cochlear blood flow in the guinea pig

Hearing Research
Z VassJ M Miller

Abstract

Physiological evidence from several studies suggests that endogenous vasoactive peptides, such as substance P (SP), and their respective receptor populations may participate in the mechanisms that govern the autoregulatory capacity of the cochlear vascular system. However, these studies do not provide evidence regarding the origin or mechanism of action of SP. Capsaicin sensitivity has been used as a marker for sensory neurons, and the release of SP following capsaicin treatment suggests a sensory transmitter role for SP. The present investigation examines the relationship between the capsaicin-sensitive sensory neurons and SP in the regulation of cochlear blood flow (CBF). In 75 pigmented guinea pigs, the cochlea was surgically exposed and a laser Doppler flowmeter probe placed on the bony surface of the first turn to monitor CBF. Capsaicin solutions (2 microliters, 0.01%, 0.001% and 0.0001%) applied to the round-window membrane (RWM) resulted in a dose-related CBF increase, without change in the systemic blood pressure. This effect could be inhibited by application of a specific SP receptor antagonist, [D-Pro2,D-Trp7,9]-SP, after which none of the capsaicin concentrations used induced a change in CBF. Moreover, after RWM appl...Continue Reading

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Citations

Dec 31, 2003·Hearing Research·C F DaiA L Nuttall
Oct 6, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·R M Bonelli, P Költringer
Apr 19, 2006·Acta Oto-laryngologica·Mitsuo TominagaTsutomu Nakashima
Mar 13, 2012·Journal of Cardiovascular Pharmacology·Noboru TodaTomio Okamura
Mar 21, 2000·The Journal of Comparative Neurology·S E ShoreR A Altschuler
Oct 22, 2019·Frontiers in Cellular Neuroscience·Asmita DhukhwaDebashree Mukherjea

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