Capsaicin-induced stimulation of polymodal nociceptors is antagonized by ruthenium red independently of extracellular calcium.

Neuroscience
R AmannF Lembeck

Abstract

The dual effect of capsaicin on primary afferent neurons, excitation and stimulation of transmitter release, its dependence on extracellular calcium and its modulation by Ruthenium Red have been investigated in the rabbit ear. Injection of capsaicin into the central artery of the isolated perfused ear with intact neuronal connection induced a reflex fall in systemic arterial blood pressure of the anaesthetized rabbit. Addition of Ruthenium Red (0.6-20 microM) to the perfusate of the ear reversibly attenuated this response in a dose-dependent manner. Perfusion of the ear with a Ca2+-free, 3 mM EGTA-containing physiological salt solution enhanced the capsaicin-evoked depressor reflex but did not prevent the inhibitory action of Ruthenium Red. Perfusion of the isolated rabbit ear with capsaicin (10 microM)-containing physiological salt solution induced the release of substance P-like immunoreactivity which was inhibited by Ruthenium Red (0.6-20 microM) and by omission of extracellular Ca2+. The results demonstrate that capsaicin-evoked transmitter release is dependent on extracellular calcium while capsaicin-evoked excitation is not reduced in a Ca2+-free perfusate. Both effects of capsaicin are potently inhibited by Ruthenium Red...Continue Reading

References

Aug 13, 1979·Life Sciences·R GamseF Lembeck
Aug 1, 1988·Acta Physiologica Scandinavica·F Lembeck
Feb 28, 1989·European Journal of Pharmacology·R Amann, F Lembeck
Jan 1, 1988·General Pharmacology·C A Maggi, A Meli
Jan 22, 1971·Biochemical and Biophysical Research Communications·C L Moore
Jun 12, 1974·Naunyn-Schmiedeberg's Archives of Pharmacology·H Juan, F Lembeck
Oct 25, 1973·Biochimica Et Biophysica Acta·V M Madeira, M C Antunes-Madeira
Jul 31, 1974·Biochimica Et Biophysica Acta·P D SwansonW L Stahl

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Citations

Sep 21, 1990·European Journal of Pharmacology·R AmannF Lembeck
Sep 4, 1990·European Journal of Pharmacology·M TakakiS Nakayama
Jan 1, 1991·Life Sciences·R Amann, C A Maggi
Apr 1, 1991·Journal of the Autonomic Nervous System·C A Maggi
May 27, 1991·Neuroscience Letters·D C BolserR W Chapman
Jul 1, 1995·Neuroscience·J García-HirschfeldM Valdeolmillos
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·L Liu, S A Simon
Jan 1, 1991·Annals of the New York Academy of Sciences·R AmannF Lembeck

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