Capsaicin: Physicochemical properties, cutaneous reactions and potential applications in painful and inflammatory conditions

Experimental and Therapeutic Medicine
Mihaela Adriana IlieDaniel Boda

Abstract

Capsaicin is a natural protoalkaloid recognized as the main pungent component in hot peppers (Capsicum annuum L.). The capsaicin receptor is highly expressed in the unmyelinated type C nerve fibers originating from small diameter sensory neurons in dorsal root ganglia and cranial nerve ganglia correspondents. Capsaicin and related vanilloids have a variety of effects on primary sensory neurons function, from sensory neuron excitation characterized by local burning sensation and neurogenic inflammation, followed by conduction blockage accompanied by reversible ultrastructural changes of peripheral nociceptive endings (desensitization), going as far as irreversible degenerative changes (neurotoxicity). The main role in capsaicin-induced neurogenic inflammation relies on the capsaicin sensitive, small diameter primary sensory neurons, therefore its evaluation could be used as a diagnostic instrument in functional alterations of cutaneous sensory nerve fibers. Moreover, capsaicin-induced desensitization and neurotoxicity explain the analgesic/anti-nociceptive and anti-inflammatory effects of topical capsaicin and its potential use in the management of painful and inflammatory conditions. In this study, we describe the effects of ca...Continue Reading

References

May 1, 1992·Agents and Actions·M Gábor, Z Rázga
Jan 1, 1992·Progress in Neurobiology·R D TreedeJ N Campbell
Jul 1, 1991·Journal of Neurophysiology·R H LaMotteE F Tsai
Jan 1, 1988·General Pharmacology·C A Maggi, A Meli
Aug 18, 1987·Brain Research·D A SimoneR H LaMotte
Jul 1, 1981·British Journal of Pharmacology·S E Carpenter, B Lynn
Aug 1, 1995·British Journal of Anaesthesia·J WinterE A Campbell
Dec 24, 1998·Journal of Neurophysiology·J SerraJ Ochoa
Feb 29, 2000·British Journal of Pharmacology·D SmartJ B Davis
May 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·S W HwangU Oh
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·S E JordtD Julius
Apr 3, 2001·Annual Review of Neuroscience·M J Caterina, D Julius
May 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·M TominagaM Masu
Sep 15, 2001·Nature·D Julius, A I Basbaum
Mar 15, 2002·Cell·Craig MontellVeit Flockerzi
May 16, 2002·Journal of Agricultural and Food Chemistry·Figen KorelYaşar Hişil
Aug 17, 2002·The Journal of Pharmacology and Experimental Therapeutics·Jennelle Durnett Richardson, Michael R Vasko
Dec 20, 2002·The Journal of Pharmacology and Experimental Therapeutics·Michael D SouthallJeffrey B Travers
Jun 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Mitsuko NumazakiMakoto Tominaga
Jul 2, 2003·The Journal of General Physiology·Sujung RyuFeng Qin
Dec 5, 2003·Nature·David E Clapham
Feb 28, 2004·European Journal of Pain : EJP·Penelope TympanidisPraveen Anand

❮ Previous
Next ❯

Citations

Jun 9, 2020·Experimental and Therapeutic Medicine·Dana Carmen ZahaSimona Bungau
Jun 9, 2020·Experimental and Therapeutic Medicine·Mihaela-Adi LupuCristiana Tanase
Jun 9, 2020·Experimental and Therapeutic Medicine·Ana Maria Alexandra StanescuCamelia Cristina Diaconu
Jun 9, 2020·Experimental and Therapeutic Medicine·Carmen BobeicăLaura Solovăstru
Jun 9, 2020·Experimental and Therapeutic Medicine·Minela Aida MaranducaIonela Lacramioara Serban
Jun 30, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cristian ScheauMonica Neagu
Feb 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cristian ScheauAna Caruntu
May 6, 2020·International Journal of Molecular Sciences·Keun-Yeong Jeong
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ariana HuditaOctav Ginghina
Jun 3, 2021·Journal of Personalized Medicine·Cristian ScheauAna Caruntu
Jul 27, 2021·Experimental and Therapeutic Medicine·Mihai-Daniel DumitracheConstantin Caruntu
Aug 28, 2021·Experimental and Therapeutic Medicine·Roxana Flavia IlieșIoan Victor Pop

❮ Previous
Next ❯

Methods Mentioned

BETA
confocal microscopy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.