Capsaicin pretreatment attenuates chronic hypoxic pulmonary hypertension

Respiration Physiology
Y L LaiH Q Zhang

Abstract

Capsaicin pretreatment was used to deplete tachykinins in order to study the role of tachykinins in chronic hypoxia-induced pulmonary hypertension. Forty three young Wistar rats weighing 235 +/- 4 g were randomly divided into four groups: control (n = 10); capsaicin pretreatment (n = 10); intermittent chronic hypoxia (n = 10); and capsaicin pretreatment + intermittent chronic hypoxia (n = 13). Control animals breathed room air. Rats in the capsaicin pretreatment groups were given capsaicin via subcutaneous injection over a three-day period. Hypobaric hypoxia was intermittently applied by placing animals into a hypobaric chamber with a barometric pressure of 380 Torr for two weeks. In the capsaicin pretreatment + intermittent chronic hypoxia group, rats were exposed to intermittent hypoxia for two weeks immediately after the last dose of capsaicin. Subsequently, pulmonary vascular function, as well as substance P (a tachykinin) level and neutral endopeptidase (NEP, the major degradation enzyme for tachykinins) activity in the lungs were measured. Chronic hypoxia caused significant increases in pulmonary artery pressure, right ventricle/(left ventricle + septum) weight ratio, hematocrit, and lung substance P level, as well as a s...Continue Reading

References

Mar 1, 1992·Journal of Applied Physiology·B Haxhiu-PoskuricaR J Martin
Mar 1, 1992·Experimental Lung Research·I M Keith, R Ekman
Jun 24, 1992·Journal of Immunological Methods·S H Jenkins
Nov 1, 1990·Experimental Lung Research·E I Bloomquist, R M Kream
May 1, 1991·Journal of Applied Physiology·M A MartinsJ M Drazen
Feb 1, 1991·Journal of Applied Physiology·Y L LaiM N Gillespie
Jul 16, 1985·Biochemical and Biophysical Research Communications·D G Payan
Aug 15, 1986·Neuroscience Letters·N LindeforsU Ungerstedt
Mar 1, 1986·Proceedings of the Society for Experimental Biology and Medicine·J C McKenzieR M Klein
Apr 1, 1985·The American Review of Respiratory Disease·M L MorganrothN F Voelkel
Aug 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·L Frank
Mar 1, 1993·Respiration Physiology·R D PetitN S Hill

❮ Previous
Next ❯

Citations

Oct 2, 2003·European Journal of Pharmacology·Bronwyn J Thomas, Janet C Wanstall
Mar 29, 2003·Toxicology and Applied Pharmacology·Mei-Jung Chen, Yih-Loong Lai
May 1, 1996·Kidney International·N D Vaziri, Z Q Wang
Jul 27, 2011·Respiratory Physiology & Neurobiology·R BhagatK Ravi
Mar 13, 2001·Toxicology and Applied Pharmacology·M J ChenY L Lai
Jun 19, 2001·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·D TschollH J Schäfers
Nov 20, 1998·Journal of Cardiovascular Pharmacology·Y L LaiC F Chen
May 18, 1999·The American Journal of Physiology·L W ChenY L Lai
Sep 15, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·T C Carpenter, K R Stenmark
Feb 8, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yih-Loong LaiChau-Fong Chen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.