PMID: 7517450Mar 1, 1994Paper

Capsaicin-sensitive stretch responses in ferret trachealis muscle

The Journal of Physiology
R F CoburnJ Alkon

Abstract

1. Stretch-induced electrical and mechanical responses in segments of ferret trachealis muscle were studied. Stretches and post-stretch length changes were quantified by measuring distances between two marker spheres placed on the muscle surface. Electrical responses were determined by measuring membrane potential in the muscle cell syncytium. 2. Smooth muscle mechanical and electrical responses to the stretch manoeuvre were characterized by an initial shortening and depolarization phase and a reversal-repolarization phase. Both phases were resistant to atropine and tetrodotoxin. During the initial phase, the membrane depolarized to potentials as low as -20 mV. For stretches to 1.0 Lmax, from a holding length of 0.75 Lmax, 50% repolarization occurred at 6.8 +/- 0.4 min post-stretch; 50% reversal of shortening of the stretched segment occurred at 6.9 +/- 0.8 min post-stretch. 3. Depolarizing currents generated within muscle cells in the stretched segment spread into cells in non-stretched muscle. Space constants in the transverse and longitudinal directions averaged 480 +/- 46 and 146 +/- 50 microns, respectively. 4. During infusion of capsaicin (10 microM), muscle cells depolarized by 5.5 +/- 2.3 mV. Maximal depolarization was ...Continue Reading

Citations

Aug 8, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Thomas K AnsellPeter K McFawn
Dec 7, 2000·American Journal of Veterinary Research·Y YamamotoY Suzuki
May 18, 2004·Journal of Applied Physiology·S R KhangureH W Mitchell
Feb 1, 1995·The American Journal of Physiology·H MatsumotoR F Coburn

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