PMID: 2484727Oct 23, 1989Paper

Capsaicin suppresses substance P-induced joint inflammation in the rat

Neuroscience Letters
F Y Lam, W R Ferrell

Abstract

Intra-articular injection of 20 micrograms substance P in rat knee joints results in a pronounced inflammatory response. However, prior intra-articular injection of 1% capsaicin solution (1-5 weeks previously) virtually abolishes this response. This is not a neurotoxic effect of capsaicin on nerve fibres as denervation of the knee produces no alteration of the response to injected substance P. The potent effect of capsaicin on substance P-mediated inflammation cannot be attributed to depletion of mast cells by this treatment as the mast cell degranulator compound 48/80 injected into capsaicin pre-treated knees still gives rise to a marked inflammatory response. Compound 48/80 does not activate nerve fibres to cause release of substance P as it is equally effective in eliciting an inflammatory response in the presence of 100 micrograms of the substance P antagonist D-Pro4, D-Trp7,9,10 SP(4-11) in the synovial cavity. The results suggest that capsaicin may act by depleting substance P receptors in joint tissue.

References

Jan 1, 1987·International Archives of Allergy and Applied Immunology·J C Foreman
Nov 1, 1989·Annals of the Rheumatic Diseases·F Y Lam, W R Ferrell
Mar 1, 1971·The Journal of Pharmacy and Pharmacology·M HaradaK Katagiri

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Citations

Nov 1, 1990·Agents and Actions·F Y Lam, W R Ferrell
Jan 1, 1993·Life Sciences·G Partsch, M Matucci-Cerinic
Feb 1, 1996·Journal of Chemical Neuroanatomy·P I MappH Cambridge
Aug 19, 2003·European Journal of Pharmacology·Francis F Y Lam, Ethel S K Ng
May 1, 1991·British Journal of Pharmacology·F Y Lam, W R Ferrell
Mar 1, 1993·British Journal of Pharmacology·F Y Lam, W R Ferrell
Jun 30, 1992·Annals of the New York Academy of Sciences·F Y Lam, W R Ferrell
Nov 1, 1991·Annals of the Rheumatic Diseases·F Y Lam, W R Ferrell
Aug 1, 1992·Annals of the Rheumatic Diseases·N E GarrettD R Blake
May 1, 1994·Annals of the Rheumatic Diseases·K A SlukaK N Westlund
May 1, 1995·Annals of the Rheumatic Diseases·P I Mapp
Dec 1, 1992·The Journal of Clinical Investigation·L J CroffordR L Wilder
Jun 13, 2000·American Journal of Veterinary Research·C A Kirker-HeadM S Kumar
Oct 1, 1996·The Journal of Orthopaedic and Sports Physical Therapy·K A Sluka
Apr 18, 1997·European Journal of Pharmacology·N B LawandK N Westlund
Jul 3, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Nicole A FrielVincent M Wang
Jun 1, 1992·Experimental and Molecular Pathology·D RobinsonZ Nevo
Nov 4, 2005·Journal of Ethnopharmacology·F Y LamJ H K Yeung
Oct 1, 1993·Pain·Hans-Georg Schaible, Blair D Grubb
Feb 5, 2010·British Journal of Pharmacology·Francis F Y Lam, Ethel S K Ng
Jan 1, 1991·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Z Davidovitch

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