Capsaicin treatment to developing rats induces increase of noradrenaline levels in the iris without affecting the adrenergic terminal density.

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
J LuthmanG Jonsson

Abstract

The effects of administration of capsaicin to developing and adult Sprague-Dawley rats on substance P-containing primary afferent and peripheral adrenergic nerves were analysed by histochemical and neurochemical techniques. In control rats a relatively dense innervation with substance P-immunoreactive fibers was seen in the iris, while 10 weeks after a single neonatal injection of capsaicin (50 mg/kg s.c.) a moderate loss of substance P-immunoreactive nerve fibers was observed. The substance P level was decreased by 60%, while the noradrenaline level, 3H-noradrenaline uptake in vitro and the noradrenaline nerve density were unaltered. Repeated injections of capsaicin (2 x 50 mg/kg, 3 x 20 mg/kg s.c.) for 5 weeks to developing rats led to a very marked decrease of the substance P level and an almost complete disappearance of substance P-immunoreactive fibers in the iris, when analysed at 10 weeks of age. The noradrenaline level in the iris was significantly increased (+42%), while no significant changes in noradrenaline level were observed in heart auricula or superior cervical ganglion. The uptake in vitro of 3H-noradrenaline in irides and heart auriculae, as well as the noradrenaline terminal density in the dilator plate and s...Continue Reading

References

Aug 18, 1978·Brain Research·T M JessellA C Cuello
Mar 1, 1976·Experimental Eye Research·A Huhtala
Mar 1, 1986·Journal of the Autonomic Nervous System·M W HouglandA E Hougland
Nov 1, 1987·Cell and Tissue Research·I StrömbergL Olson
Oct 1, 1986·Acta Physiologica Scandinavica·J Luthman, H Hallman
Oct 1, 1973·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·C Sachs, G Jonsson
Oct 1, 1970·Acta Physiologica Scandinavica·J De ChamplainC Sachs
Jan 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J A Kessler, I B Black
May 29, 1981·Neuroscience Letters·A MillerI W Chubb
Mar 1, 1984·The Journal of Comparative Neurology·A SeigerH Björklund
Jan 1, 1981·Journal of Immunological Methods·G D Johnson, G M Nogueira Araujo
Nov 8, 1958·Nature·C C CURTAIN
Jan 1, 1982·Neurochemistry International·J V PriestleyA C Cuello

❮ Previous
Next ❯

Citations

Feb 1, 1991·Naunyn-Schmiedeberg's Archives of Pharmacology·O D HottensteinE D Jacobson
Apr 1, 1994·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M M BrauerG Burnstock
Oct 1, 1994·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M M BrauerG Burnstock
Feb 13, 2001·Neuroscience and Biobehavioral Reviews·M M MauerT J Bartness
Mar 1, 2001·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Donna H Wang, Yan Huang
Aug 22, 2007·The American Journal of Chinese Medicine·Chun-Sang YooJae-Young Um
Aug 1, 1997·Acta Odontologica Scandinavica·I Fristad

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.