PMID: 16636441Apr 26, 2006Paper

Capsiate, a nonpungent capsaicin analog, increases endurance swimming capacity of mice by stimulation of vanilloid receptors

Bioscience, Biotechnology, and Biochemistry
S HaramizuTohru Fushiki

Abstract

We investigated the effect of capsiate, a nonpungent natural capsaicin analog, on the swimming capacity of mice in an adjustable-current water pool. Male BALB/c mice orally given capsiate (10 mg/kg) were able to keep swimming longer before exhaustion than the control mice. After 30 min of swimming, the residual glycogen in the gastrocnemius muscle was higher, the serum free fatty acid concentration tended to be higher, and the serum lactic acid concentration was significantly lower in the capsiate-administered mice. The value for the respiratory exchange ratio of the capsiate group was significantly lower during both resting and treadmill running. These physiological differences were abolished by administering the vanilloid receptor antagonist, capsazepin (0.17 mmol/kg, i.p.). The mice were not averse to the capsiate solution during a 4-h two-bottle choice test. These results suggest that the oral administration of capsiate enhanced fat oxidation and spared carbohydrate utilization, and consequently increased the endurance swimming capacity of the mice via stimulation of their vanilloid receptors. Practical application of capsiate is expected.

References

Aug 1, 1974·Analytical Biochemistry·J V Passonneau, V R Lauderdale
Oct 1, 1967·Acta Physiologica Scandinavica·J BergströmB Saltin
Dec 1, 1965·Acta Physiologica Scandinavica·L Lundholm, N Svedmyr
Feb 11, 1999·Bioscience, Biotechnology, and Biochemistry·K M KimT Fushiki
Apr 3, 2001·Annual Review of Neuroscience·M J Caterina, D Julius
Oct 26, 2001·Bioscience, Biotechnology, and Biochemistry·K OhnukiT Fushiki
Jul 3, 2002·Bioscience, Biotechnology, and Biochemistry·Wataru MizunoyaTohru Fushiki
Sep 18, 2003·The British Journal of Nutrition·Tae-Woong OhFukio Ohta

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Citations

Jun 9, 2009·Bioscience, Biotechnology, and Biochemistry·Yanghee YouWoojin Jun
Dec 6, 2008·The American Journal of Clinical Nutrition·Soren SnitkerMichio Takahashi
Jan 19, 2008·Journal of Nutritional Science and Vitaminology·Guihua ZhangEiji Shimizu
Jan 28, 2010·Geriatrics & Gerontology International·Miyako YamasakiMasahiro Kohzuki
Nov 26, 2014·Molecular Medicine Reports·Qin HongYuan Quan
Jan 19, 2018·International Journal of Sport Nutrition and Exercise Metabolism·Mark Elisabeth Theodorus WillemsMatthew David Cook
Mar 20, 2014·American Journal of Physiology. Endocrinology and Metabolism·Yashiro KazuyaBenoît Giannesini
May 18, 2020·European Journal of Nutrition·Russ BestCraig Pickering
Dec 18, 2014·American Journal of Physiology. Endocrinology and Metabolism·Kana OhyamaMakoto Bannai
Jan 1, 2021·International Journal of Sports Physiology and Performance·Vilton E L de Moura E SilvaFabrício E Rossi
May 7, 2021·Critical Reviews in Food Science and Nutrition·Reena GuptaAnkit Awasthi
Jun 6, 2009·Journal of Agricultural and Food Chemistry·Yoshiyuki TanakaSusumu Yazawa

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