PMID: 9178496May 1, 1997Paper

Capsid protein composition of reference strains and wild isolates of human astroviruses

Virus Research
G BelliotS S Monroe

Abstract

Astroviruses are small RNA viruses that are frequently associated with gastroenteritis in humans and animals. Despite much work on the genetic analysis of astrovirus strains, little progress has been made in the characterization of the proteins composing mature virions. We have analyzed the capsid protein composition of the reference strains and several wild isolates of human astroviruses using high-resolution polyacrylamide gradient gels. For reference strains of the seven serotypes analyzed, a consistent pattern of three infection-specific proteins--designated P1, P2, and P3 -was generally observed. The strains could be divided into two groups, based upon the reactivity of these proteins in immune precipitation assays that used homologous rabbit serum. One group included reference types 1 4 for which all three proteins were precipitated by homologous rabbit sera; for the other group, types 5 7, only proteins P2 and P3 were precipitated. When wild isolates from around the world were compared to the reference strains, a correlation between genetic type and the pattern of protein sizes and immune reactivity was observed for strains of the common types (1-4). Strains of types 2 and 4 consistently exhibited P3 proteins larger than...Continue Reading

References

Jul 19, 1975·Lancet·C R Madeley, B P Cosgrove
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Jun 20, 1991·The New England Journal of Medicine·J E HerrmannN R Blacklow
Jan 1, 1990·Archives of Virology·M M WillcocksC R Madeley
Mar 1, 1981·The Journal of General Virology·A J HerringD R Snodgrass
Dec 1, 1981·The Journal of General Virology·T W Lee, J B Kurtz
Jan 1, 1995·Archives of Virology·T L Lewis, S M Matsui
Jul 1, 1994·The Journal of General Virology·M M WillcocksM J Carter
Jul 1, 1993·The New England Journal of Medicine·G S GrohmannR T Bryan
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·B JiangR I Glass
Sep 21, 2000·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·O TraoréS Billaudel

❮ Previous
Next ❯

Citations

Jun 26, 2001·Journal of Medical Virology·Q H WangH Ushijima
Feb 13, 2001·Journal of Virological Methods·G M BelliotS S Monroe
Aug 17, 2000·Journal of Applied Microbiology·C D ChapronA B Margolin
Jan 22, 2000·Journal of Virology·D M Bass, S Qiu
Jul 23, 2002·Journal of Virology·Ernesto MéndezCarlos F Arias
Nov 16, 2004·Journal of Virology·Santiago CaballeroRosa M Pintó
Jun 21, 2002·The Journal of General Virology·Ute GeigenmüllerSuzanne M Matsui
Apr 12, 2001·The Journal of General Virology·C M JonassenB Grinde
Aug 9, 2005·Journal of Proteome Research·Sudhir SrivastavaRashmi Gopal-Srivastava

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.