PMID: 9423888Jan 10, 1998Paper

Capsular polysaccharide-fimbrial protein conjugate vaccine protects against Porphyromonas gingivalis infection in SCID mice reconstituted with human peripheral blood lymphocytes

Infection and Immunity
J-I ChoiB W Kim

Abstract

The effect of immunization with either a Porphyromonas gingivalis fimbrial protein, a capsular polysaccharide, or a capsular polysaccharide-fimbrial protein conjugate vaccine were compared in hu-PBL-SCID mice. A significantly higher human immunoglobulin G antibody response and the highest degree of in vivo protection against bacterial challenge was observed in the group immunized with the conjugate vaccine. It was concluded that capsular polysaccharide-fimbrial protein conjugate from P. gingivalis could potentially be developed as a vaccine against periodontal infection by P. gingivalis.

References

Jul 1, 1991·Journal of Clinical Periodontology·G J Seymour
Feb 10, 1983·Nature·G C BosmaM J Bosma
Jan 1, 1995·Annual Review of Immunology·J J MondC M Snapper

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Citations

Oct 16, 1999·Periodontology 2000·S C HoltC A Genco
Jan 18, 2008·Journal of Clinical Periodontology·Dana T GravesGeorge Hajishengallis
Mar 26, 2003·Oral Microbiology and Immunology·J-I ChoiH-R Park
Sep 10, 2010·Journal of Periodontal & Implant Science·Jeom-Il Choi, Gregory J Seymour
Jan 30, 2010·Expert Review of Vaccines·Rosa A M Jong, Wil A van der Reijden
May 17, 2005·Anais Da Academia Brasileira De Ciências·Christopher Jones
Apr 26, 2012·FEMS Microbiology Letters·Nagihan Bostanci, Georgios N Belibasakis
Aug 3, 2007·Expert Review of Vaccines·Dileep C G SharmaBangalore Varadhan Karthikeyan

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