PMID: 9533721Apr 9, 1998Paper

Capsule genetics in Streptococcus pneumoniae and a possible role for transposition in the generation of the type 3 locus

Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease
M J CaimanoJanet Yother

Abstract

The capsule genes of Streptococcus pneumoniae have a cassette-like organization in which the type-specific biosynthetic genes are flanked by genes shared among the different capsular serotypes. This general organization has been identified in the capsule loci of all serotypes analyzed to date, but significant differences that may help explain novel capsule type formation are beginning to emerge. In particular, analysis of the type 3 locus has revealed its most striking feature to be a preponderance of partial genes that have homology to sequences involved in polysaccharide biosynthesis and transposition. The predicted proteins of cps3M, the most downstream type 3-specific gene, and tnpA and plpA, the non-type-specific flanking sequences downstream of cps3M, have homologies with phosphomutases, transposases, and peptide permeases, respectively. All three of these sequences are truncated when compared to their respective homologs. Mutation and transcription analyses of these partial sequences showed that none of these sequences is essential for type 3 polysaccharide synthesis but that all are transcribed. Partial sequences were also identified in the region upstream of the type 3-specific genes. The type 3 locus structure is cons...Continue Reading

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Citations

Feb 27, 1999·Current Opinion in Microbiology·E Tuomanen
Jan 25, 2003·Antimicrobial Agents and Chemotherapy·Kimberly A NicholDaryl J Hoban
May 12, 2001·Infection and Immunity·A D Magee, J Yother
Nov 10, 2006·Journal of Clinical Microbiology·M Catherine McEllistremSaleem A Khan
Jun 19, 2015·Clinical Microbiology Reviews·K Aaron GenoMoon H Nahm
Jun 9, 2005·Microbiology·Daniel LlullSaulius Kulakauskas
Feb 8, 2000·The Journal of Biological Chemistry·R T CarteeJ Yother
Jun 1, 2004·Nature Reviews. Genetics·Franco Pagani, Francisco E Baralle
Oct 19, 2001·The Journal of Biological Chemistry·M H Bender, J Yother
Nov 15, 2018·Frontiers in Microbiology·N Luisa Hiller, Raquel Sá-Leão
Oct 22, 2019·Frontiers in Microbiology·Prachetash GhoshDong Kwon Rhee

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