Abstract
To determine the added value of capsule, septum, and T2 hyperintense foci for differentiating large hepatocellular carcinoma (HCC; ≥ 5 cm) from intrahepatic cholangiocarcinoma (ICC) using gadoxetic acid MRI. The study included 116 patients (94 men, 22 women; mean age, 56.8 years) with surgically confirmed HCCs (n = 87, 5.0-18.0 cm) or ICCs (n = 29, 5.0-14.0 cm) who underwent gadoxetic acid MRI. Three observers independently reviewed MRIs in two sessions, examining enhancement patterns only and then adding capsule, septum, and T2 hyperintense foci. Reviewers used a five-point scale to score accuracy, sensitivity, and specificity. A significant increase was observed in accuracy when ancillary features (96.1-98.3%) were added compared to enhancement pattern only (83.6-88.4%; p ≤ 0.02). Sensitivity was significantly increased with combined reading (97.1-98.3%) compared to enhancement features only (81.6-88.5%; p ≤ 0.006) for two observers, with no difference in specificity (84.5-89.7% vs. 86.2-98.3%; p > 0.05). We found substantial to excellent interobserver agreement for ancillary features (0.598-0.976). Adding capsule, septum, and T2 hyperintense foci to enhancement patterns for gadoxetic acid MRI increased diagnostic performance...Continue Reading
References
Jun 1, 1992·Radiology·M KadoyaA Nonomura
Jul 1, 1993·Radiology·L Martí-BonmatíJ S Vilar
May 1, 1954·Cancer·H A EDMONDSON, P E STEINER
Feb 21, 2004·AJR. American Journal of Roentgenology·K H Y LeeA Hanbidge
Mar 21, 2006·European Radiology·Jae Hoon LimHyo Keun Lim
Oct 31, 2007·Journal of Magnetic Resonance Imaging : JMRI·Indra C van den BosGabriel P Krestin
Nov 22, 2007·AJR. American Journal of Roentgenology·Su Jin KimByung Ihn Choi
May 16, 2008·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Robert F HannaClaude B Sirlin
Dec 20, 2008·Radiology·Kousei IshigamiHiroshi Honda
Jun 24, 2009·Digestive Diseases·Christoph J ZechKarin A Herrmann
Aug 3, 2010·Journal of Magnetic Resonance Imaging : JMRI·Asra S KhanJorge A Marrero
Nov 26, 2010·Magnetic Resonance Imaging Clinics of North America·Gaurav KhatriFrank H Miller
Jun 28, 2011·AJR. American Journal of Roentgenology·Young Joo SuhKi Whang Kim
Sep 21, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixCarmen Ayuso
Nov 16, 2011·Journal of Computer Assisted Tomography·Yuko NakamuraKazuo Awai
Mar 16, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Jing XuYasuni Nakanuma
Mar 20, 2012·Clinical Radiology·Y S ChongS J Lee
Jul 26, 2012·Abdominal Imaging·Hyun Jeong ParkWon Jae Lee
Aug 18, 2012·Magnetic Resonance Imaging·Naoki KanataKazuro Sugimura
Jan 1, 2010·Oncology Letters·Masaru FujimotoHirohisa Yano
Oct 26, 2013·Liver Cancer·Simona BotaLuigi Bolondi
Jul 27, 2014·European Radiology·Nobuhiro FujitaHiroshi Honda
Aug 26, 2014·Radiology·Jin-Young ChoiClaude B Sirlin
Feb 24, 2015·Diagnostic and Interventional Radiology : Official Journal of the Turkish Society of Radiology·Yoshiki AsayamaHiroshi Honda
Jun 14, 2015·European Radiology·Elmar M MerkleMengsu Zeng
Jul 22, 2015·European Radiology·E NeriC Bartolozzi
Sep 17, 2015·European Radiology·Rihyeon KimByung Ihn Choi
Dec 5, 2015·European Radiology·Hyun Jeong ParkJuna Goo
Jan 29, 2016·Journal of Hepatology·Sang Hyun ChoiPyo Nyun Kim
Mar 10, 2016·Journal of Computer Assisted Tomography·Eric M BlaschkeAytekin Oto
Apr 19, 2016·Journal of Magnetic Resonance Imaging : JMRI·Ijin JooJoon Koo Han
Oct 23, 2016·European Radiology·Chansik AnSumi Park
Citations
Jan 18, 2018·European Radiology·Seo-Youn ChoiHojeong Won
Aug 15, 2019·Nanomedicine·Qunfang ZhouPing Liang
Jan 7, 2020·Cancer Medicine·Lang ChenGuangtong Deng
Oct 3, 2018·Journal of Magnetic Resonance Imaging : JMRI·Xianlun ZouIhab R Kamel
Jul 5, 2019·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Jae Hyun KimJeong Min Lee
Aug 7, 2019·European Radiology·Christoph J ZechDow-Mu Koh
Jan 22, 2019·Clinical and Molecular Hepatology·Yeun-Yoon KimMyeong-Jin Kim
Nov 28, 2020·European Radiology·Hanyu JiangMustafa R Bashir
Mar 23, 2021·Canadian Journal of Gastroenterology & Hepatology·Ying-Ying LiangJin Wang
Feb 2, 2019·Clinical Radiology·M-W You, S J Yun