PMID: 9545521May 28, 1998Paper

Capsulin: a novel bHLH transcription factor expressed in epicardial progenitors and mesenchyme of visceral organs

Mechanisms of Development
J LuE N Olson

Abstract

Members of the basic helix-loop-helix (bHLH) family of transcription factors have been shown to control development and differentiation of a variety of cell types. We describe a novel bHLH protein, called capsulin, which is expressed specifically in mesodermally-derived cells that surround the epithelium of the developing gastrointestinal, genitourinary and respiratory systems during mouse embryogenesis. Capsulin transcripts also mark the spiral septum of the heart and progenitor cells that give rise to the pericardium and coronary arteries. Capsulin shares high homology with a recently identified bHLH protein from Drosophila, called bHLH102C, which is expressed in visceral muscle cells that surround the midgut. Capsulin binds a specific E-box consensus sequence (CANNTG) as a heterodimer with the widely-expressed bHLH protein E12, but it does not activate transcription through that sequence on its own. Its restricted expression pattern and DNA binding activity suggest that capsulin regulates gene expression in specific subtypes of visceral mesodermal cells involved in organogenesis and in precursor cells that contribute to the pericardium, coronary arteries and regions of the heart.

References

Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·T Mikawa, D A Fischman
Feb 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·C G BegleyN M Gough
Sep 1, 1981·The Anatomical Record·S Virágh, C E Challice
Dec 22, 1995·Science·D SrivastavaE N Olson
Aug 1, 1996·Current Opinion in Genetics & Development·J D Molkentin, E N Olson
Mar 1, 1995·Trends in Cardiovascular Medicine·D M NodenA C Gittenberger-de Groot

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Citations

Jun 2, 2012·Journal of Cardiovascular Translational Research·Jan Schlueter, Thomas Brand
Oct 24, 2002·Matrix Biology : Journal of the International Society for Matrix Biology·Wan-Ming ZhangDonald Gullberg
Nov 7, 2009·Circulation Research·Paige SniderSimon J Conway
Nov 26, 2010·Circulation Research·Jamie L RussellJay W Schneider
May 1, 2009·Endocrine Reviews·Alex C KimGary D Hammer
Jul 3, 2010·PloS One·Lars BochmannNadia Rosenthal
Jul 14, 2012·PloS One·Yoshiro MaezawaSusan E Quaggin
Aug 16, 2000·Proceedings of the National Academy of Sciences of the United States of America·J LuE N Olson
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·C L ZhangE N Olson
Jan 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Laura T SmithChristoph Plass
Dec 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·N FreyE N Olson
Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·J LuE N Olson
Aug 27, 2014·Journal of Cancer Research and Clinical Oncology·Z YangD Q Dai
May 26, 2012·Stem Cell Reviews and Reports·David C GajzerHina W Chaudhry
Jan 10, 2016·Journal of Molecular and Cellular Cardiology·Thomas Moore-MorrisSylvia M Evans
Jan 2, 2016·Journal of Molecular and Cellular Cardiology·Janet K Lighthouse, Eric M Small
Dec 17, 2011·Science China. Life Sciences·JianZhong LiYoshitaka Nagahama
Jul 16, 2010·Protein Expression and Purification·Chi-Yuan ChouYau-Hung Chen
Jan 24, 2007·Molecular and Cellular Endocrinology·Alex C Kim, Gary D Hammer
May 7, 2009·Annals of the New York Academy of Sciences·Mary FamilariLaura J Parry
Mar 25, 2011·Genesis : the Journal of Genetics and Development·Asha AcharyaMichelle D Tallquist
Oct 1, 2015·BioMed Research International·Monica Malheiros FrançaClaudimara Ferini Pacicco Lotfi
Aug 11, 2015·Current Biology : CB·Danielle NagelbergHolger Knaut
Jul 15, 2015·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Thomas Moore-MorrisSylvia M Evans
Jan 8, 2000·Developmental Biology·C MacNeillJ B Burch
Jan 15, 2013·Molecular and Cellular Endocrinology·Monica Malheiros FrançaClaudimara F P Lotfi
Oct 31, 2013·Epigenetics : Official Journal of the DNA Methylation Society·Pauline M W van KempenWilko Grolman
Apr 20, 1999·Developmental Biology·D E ReeseD Bader

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