Captivating capture: how microtubules attach to kinetochores

Current Biology : CB
S Biggins, C E Walczak

Abstract

Accurate chromosome segregation is essential to ensure genomic stability because the aneuploidy that results from segregation errors leads to birth defects and contributes to the development of cancer. Chromosome segregation is directed by the kinetochore, the chromosomal site of attachment to dynamic polymers called microtubules (MTs). Although the fidelity of chromosome segregation depends on precise interactions between kinetochores and MTs, it is still unclear how this interaction is mediated and regulated. Here we discuss current progress in determining how kinetochores assemble and attach to MTs during mitosis as well as how they correct errors.

References

Jul 1, 1992·The Journal of Cell Biology·K L McDonaldJ R McIntosh
Nov 15, 1984·Nature·T Mitchison, M Kirschner
Jan 1, 1981·Chromosoma·H Ris, P L Witt
Dec 8, 1995·Science·K S McKim, R S Hawley
Jun 1, 1995·The Journal of Cell Biology·M WineyJ R McIntosh
Feb 16, 1995·Nature·X Li, R B Nicklas
Nov 1, 1994·The Journal of Cell Biology·P K SorgerA A Hyman
Sep 1, 1994·The Journal of Cell Biology·R B Nicklas, S C Ward
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·T E Holy, S Leibler
May 1, 1993·The Journal of Cell Biology·P Y Goh, J V Kilmartin
Mar 1, 1996·Molecular and Cellular Biology·M M SmithP C Megee
Sep 23, 1997·The Journal of Cell Biology·D A StarrM L Goldberg
Feb 12, 1998·The Journal of Cell Biology·B T SchaarT J Yen
Dec 18, 1997·American Journal of Human Genetics·K H Choo
Jun 20, 1998·The Journal of Cell Biology·D DujardinJ R De Mey
May 21, 1998·Nature Biotechnology·M IkenoH Masumoto
Aug 12, 1998·The Journal of Cell Biology·D A StarrM L Goldberg
Aug 12, 1998·The Journal of Cell Biology·T ManeyL Wordeman
Feb 16, 1999·Cell·A DesaiC E Walczak

❮ Previous
Next ❯

Citations

Feb 4, 2006·Journal of Biomedical Science·Li MaXueliang Zhu
Oct 21, 2003·Molecular Biology of the Cell·Vladimir S NekrasovJohn V Kilmartin
Jan 28, 2005·Molecular Biology of the Cell·Nathaniel S Edwards, Andrew W Murray
Oct 7, 2005·Molecular Biology of the Cell·Kimberly A CollinsSue Biggins
Apr 21, 2006·Molecular Biology of the Cell·Per HolmfeldtMartin Gullberg
Apr 25, 2007·Nucleic Acids Research·Hideaki OgiwaraMasayuki Seki
Dec 1, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Joanna Rutkowska, Alexander V Badyaev
Sep 17, 2003·Genes & Development·Judith A SharpPaul D Kaufman
May 25, 2010·Eukaryotic Cell·Anna SelmeckiJudith Berman
Oct 8, 2004·Eukaryotic Cell·Tanja Stoyan, John Carbon
May 5, 2005·Molecular and Cellular Biology·Vinciane RégnierWilliam Brown
Mar 16, 2006·Molecular and Cellular Biology·Benjamin A PinskySue Biggins
May 10, 2005·Annual Review of Microbiology·Gianni Liti, Edward J Louis
Jun 3, 2009·Journal of Biomedical Science·Hsing-Hsi LiGwo-Jen Liaw
Jun 27, 2006·BMC Cell Biology·Jane R StoutClaire E Walczak
Dec 3, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·Stephane Brunet, Bernard Maro
Sep 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Vivien MeasdayBrenda Andrews
Jun 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Christopher J BakalRobert Rottapel
Sep 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Suzanne Furuyama, Sue Biggins
Aug 19, 2008·Biochimica Et Biophysica Acta·Floris FoijerPeter K Sorger
Dec 11, 2007·Mutation Research·Fengyun SunUrsula Eichenlaub-Ritter
Aug 16, 2006·Biology of the Cell·Jean-Baptiste Manneville, Sandrine Etienne-Manneville
Oct 20, 2005·Current Opinion in Cell Biology·Karen W Y YuenPhilip Hieter
Jul 19, 2005·Trends in Cell Biology·Daniela Cimini, Francesca Degrassi
May 6, 2014·Molecular Cell·Jun YanYue Xiong
Jul 25, 2006·Current Biology : CB·Michiya NishinoLi-Yuan Yu-Lee
Jul 12, 2005·Current Biology : CB·Kerry Bloom
Sep 19, 2003·Current Biology : CB·Alex Mogilner, George Oster
Nov 24, 2004·Current Biology : CB·Jennifer D Banks, Rebecca Heald
Nov 9, 2004·Current Biology : CB·Chad G PearsonKerry Bloom
Apr 6, 2005·Developmental Cell·Stephan W Grill, Anthony A Hyman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.