Captopril alters schedule induced polydipsia, urination, and defecation in rats

Pharmacology, Biochemistry, and Behavior
R L BowersK May

Abstract

Schedule induced polydipsia, urination and defecation were examined in rats that received training on a fixed interval 2 min schedule of food reinforcement. In Phase I of the experiment, animals received peripheral injections of captopril (an angiotensin conversion enzyme blocker, 0.5 or 50 mg/kg), or equivalent volumes of 0.9% saline. The results showed that low doses of captopril (0.5 mg/kg) significantly increased both operant responding and the adjunctive behaviors. High peripheral doses of captopril significantly reduced responding and schedule induced behavior. In Phase II of the experiment, animals received either low peripheral doses of captopril (sc 0.5 mg/kg), or low doses that were coupled with central injections (i.e., 0.12 mg icv + 0.5 mg/kg sc). As observed in Phase I, low peripheral doses of captopril enhanced behavior, but the enhancement effect was eliminated with low (0.12 mg) central administration. The overall results are consistent with past research examining captopril effects on non-operant, meal-induced drinking. Yet since captopril affected operant responding and adjunctive behaviors similarly, the findings suggest that angiotensin plays a common role in the motivational processes that precede and follo...Continue Reading

References

Oct 1, 1979·Journal of Comparative and Physiological Psychology·L P Brett, S Levine
Jan 1, 1992·Research in Developmental Disabilities·E Emerson, D Howard
Jun 12, 1992·Annals of the New York Academy of Sciences·J P BurbachF M de Bree
Jun 12, 1992·Annals of the New York Academy of Sciences·C S CarterT R Insel
Jun 1, 1990·Behavioral Neuroscience·G MittlemanT W Robbins
Sep 1, 1989·Pharmacology, Biochemistry, and Behavior·L A GruppR B Stewart
May 1, 1987·Baillière's Clinical Endocrinology and Metabolism·E A Espiner
Aug 1, 1973·Physiology & Behavior·H J Carlisle
Jun 1, 1973·Journal of Comparative and Physiological Psychology·E C LotterJ R Vasselli
May 1, 1971·Physiology & Behavior·J L Falk
Mar 1, 1969·Journal of Comparative and Physiological Psychology·H R Kissileff
Sep 1, 1983·General and Comparative Endocrinology·J X Wilson, D G Butler
Jan 1, 1982·Neuroscience and Biobehavioral Reviews·C L Wetherington
Feb 1, 1981·Physiology & Behavior·L P Brett, S Levine
Jan 1, 1995·Brain Research Bulletin·P M SmithA V Ferguson
Mar 1, 1994·Pharmacology, Biochemistry, and Behavior·B J Cole, G F Koob

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