PMID: 7021045Sep 1, 1981Paper

Captopril attenuates adrenergic vasoconstriction in rat mesenteric arteries by angiotensin-dependent and -independent mechanisms

Clinical Science
M G Collis, J R Keddie


1. Angiotensin-converting enzyme inhibitors can attenuate reflex sympathetic vasoconstriction in vivo. We have investigated the effects of captopril (SQ 14 225) on adrenergic vasoconstrictor mechanisms in isolated, Krebs-Ringer solution perfused, rat mesenteric arteries. 2. Low concentrations of captopril (2 X 10(-6) mol/l) did not alter the vasoconstrictor response evoked by sympathetic nerve stimulation. 3. Exogenous angiotensin I and II did not have a direct vasoconstrictor effect, but caused dose-related increases in the amplitude of responses induced by nerve stimulation. 4. The potentiating effect of angiotensin I was antagonized by captopril (6.7 X 10(8)-2 X 10(-6) mol/l) and by saralasin (10(-8) mol/l). The potentiating effect of angiotensin II was antagonized by saralasin only. 5. In the absence of exogenous peptides high concentrations of captopril (1 X 10(-4)-3 X 10(-4) mol/l) antagonized vasoconstrictor responses evoked by sympathetic nerve stimulation and exogenous noradrenaline, but not those evoked by potassium chloride. 6. These results indicate that captopril can have two types of inhibitory effect at the adrenergic neuro-effector junction. High concentrations antagonize responses to noradrenaline and nerve sti...Continue Reading


Jan 1, 1983·Clinical and Experimental Hypertension. Part A, Theory and Practice·D P CloughR Hatton
Jan 1, 1983·Clinical and Experimental Hypertension. Part A, Theory and Practice·T UngerR E Lang
Jan 1, 1987·Clinical and Experimental Hypertension. Part A, Theory and Practice·R R VollmerV S Murthy
Jan 1, 1982·Clinical and Experimental Hypertension. Part A, Theory and Practice·A P NiarchosJ H Laragh
May 31, 1984·The American Journal of Medicine·I R CrossleyR Williams
Mar 15, 1989·Biochemical Pharmacology·P PalatiniP Finotti
Jan 1, 1989·British Journal of Clinical Pharmacology·P M VanhoutteM J Vidal
Jan 23, 2015·Frontiers in Neuroscience·Hussain Al Dera, James A Brock
Jul 26, 2006·Hypertension·Ivan A ArenasSandra T Davidge
Jan 1, 1989·Pharmacotherapy·M R UjhelyiP H Vlasses
Mar 1, 1988·British Journal of Clinical Pharmacology·G B KondoweD W Harron

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Separation Anxiety

Separation anxiety is a type of anxiety disorder that involves excessive distress and anxiety with separation. This may include separation from places or people to which they have a strong emotional connection with. It often affects children more than adults. Here is the latest research on separation anxiety.

KIF1A Associated Neurological Disorder

KIF1A associated neurological disorder (KAND) is a rare neurodegenerative condition caused by mutations in the KIF1A gene. KAND may present with a wide range and severity of symptoms including stiff or weak leg muscles, low muscle tone, a lack of muscle coordination and balance, and intellectual disability. Find the latest research on KAND here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Related Papers

Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension
M NakamaruT Ogihara
Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension
J Ziogas, D F Story
© 2021 Meta ULC. All rights reserved