Captopril enhances in vitro human lymphocyte thymidine incorporation

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M R SimonL M Howard

Abstract

Angiotensin-converting enzyme activity is present in human sarcoid as well as murine schistosome granulomas. Inhibition of angiotensin-converting enzyme by captopril results in decreased granuloma size in animals. Since captopril is used clinically to treat hypertension, its effect on human lymphocyte thymidine incorporation was determined. It was found that 5 X 10(-5) M and 10(-4) M captopril enhances lymphocyte thymidine uptake induced by 25 micrograms/ml phytohaemagglutinin-P. This suggests that captopril can alter immunological reactivity in man and that angiotensin-converting enzyme may have an immunological function.

References

Jan 1, 1976·Annual Review of Biochemistry·R L Soffer
Apr 1, 1977·Physiological Reviews·M J Peach
Oct 1, 1977·Annals of Internal Medicine·J Lieberman, T H Rea
Aug 14, 1978·Biochemical and Biophysical Research Communications·J FriedlandE Silverstein
Dec 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E SilversteinJ Friedland

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Citations

Mar 7, 2002·Journal of the Renin-angiotensin-aldosterone System : JRAAS·A SonmezM Ozata
Jun 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lisa M GodselDavid M Engman

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