Abstract
The potential inhibitory effects of captopril, the angiotensin-converting enzyme inhibitor, on thioacetamide (TAA)-induced hepatic mammalian target of rapamycin (mTOR), liver injury enzymes, blood pressure, and biomarkers of inflammation and oxidative stress have not been investigated before. Rats were either injected with TAA (200 mg/kg; twice a week for 8 weeks) before being sacrificed after 10 weeks (model group) or were pretreated with captopril (150 mg/kg) daily for two weeks prior to TAA injections and continued receiving both agents until the end of the experiment (protective group). Captopril significantly (p < .05) inhibited TAA-induced hypertension, liver tissue levels of mTOR, TIMP-1, TNF-α, IL-6, MDA; and blood levels of lipids, ALT, and AST. We further demonstrated a significant (p < .01) positive correlation between mTOR scoring and the levels of inflammatory, oxidative and liver injury biomarkers. Captopril protects against TAA-induced mTOR, liver injury enzymes, dyslipidemia, hypertension, inflammation, and oxidative stress.
References
Apr 1, 1991·Liver·T NouchiF Marumo
Mar 27, 2001·Toxicology and Applied Pharmacology·L A MorioD L Laskin
Jul 5, 2001·Gastroenterology·J R JonssonE E Powell
Feb 20, 2003·Journal of Hepatology·Scott L Friedman
Apr 13, 2005·Hypertension·Zvi AckermanBen-Ami Sela
Dec 14, 2005·Hypertension·Ruben O HalperinJ Michael Gaziano
Mar 23, 2006·World Journal of Gastroenterology : WJG·Yue-Hong HuangXiao-Zhong Wang
Jun 10, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Martin RoderfeldElke Roeb
Oct 20, 2006·Journal of Hepatology·Markus NeefJuerg Reichen
Mar 29, 2007·Circulation·Melissa CudmoreAsif Ahmed
Jan 15, 2008·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Golnar KarimianBehnam Shakiba
Feb 4, 2010·Hypertension·Bahjat Al-AniAsif Ahmed
Apr 2, 2010·Journal of Korean Medical Science·Soo Young ParkJa-June Jang
Apr 21, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Natalie BzowejUNKNOWN PHOENIX Study Group
Jul 13, 2013·Toxicology Letters·Qunyan YaoChuantao Tu
Nov 28, 2013·Fibrogenesis & Tissue Repair·Christian LiedtkeRalf Weiskirchen
Jan 10, 2014·PloS One·Weijie WangHongwei Li
Mar 15, 2014·World Journal of Gastroenterology : WJG·Albert J Czaja
Jul 11, 2014·World Journal of Gastroenterology : WJG·Halina Cichoż-Lach, Agata Michalak
Dec 3, 2014·Fitoterapia·Yanling ZhaoXiaohe Xiao
Apr 4, 2015·Laboratory Animals·M C WallaceS L Friedman
Nov 6, 2015·International Journal of Molecular Sciences·Sha LiYibin Feng
Nov 19, 2015·Acta Pharmaceutica Sinica. B·Georgina N Masoud, Wei Li
Jul 2, 2016·Toxicology Letters·Yan-Ling WuJi-Xing Nan
Sep 18, 2016·The Kaohsiung Journal of Medical Sciences·Qi-Hong YuZhao-Shen Li
Oct 31, 2016·Life Sciences·Azam AbareshiAkbar Anaeigoudari
Nov 8, 2016·Scientific Reports·Lanlan ShanMeng Dai
Nov 11, 2016·Advances in Medicine·Azam AbareshiMahmoud Hosseini
Nov 23, 2016·Saudi Journal of Biological Sciences·Badr A Aldahmash, Doaa M El-Nagar
Feb 6, 2017·Scientific Reports·G AntonacciG Ruocco
Oct 3, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Nesrine S El-MezayenAiman S El-Khatib
Oct 6, 2017·Oncotarget·Zhenxing LiangYang Yang
Nov 22, 2017·Scientific Reports·Junping HuNingjun Li
Mar 30, 2018·Digestive Diseases and Sciences·Nahla E El-AshmawyOmnia B Hamada
May 31, 2018·Experimental Lung Research·Javad BoskabadiMohammad Hossein Boskabady
Oct 7, 2018·Inflammopharmacology·Javad BoskabadiMohammad Hossein Boskabady
Oct 10, 2018·American Journal of Physiology. Endocrinology and Metabolism·Justin LoloiAmy C Arnold
Jan 30, 2019·Drug and Chemical Toxicology·Farimah BeheshtiAkbar Anaeigoudari