PMID: 9546217Apr 18, 1998Paper

Capture of an early fusion-active conformation of HIV-1 gp41

Nature Structural Biology
R A FurutaC D Weiss

Abstract

Using an inhibitory synthetic peptide (DP-178) from HIV-1 gp41, we have trapped HIV-1 envelope glycoprotein (Env) undergoing conformational changes during virus entry. Our data show that DP-178 binds gp41 and inhibits Env-mediated membrane fusion after gp120 interacts with cellular receptors, indicating that conformational changes involving the coiled coil domain of gp41 are required for entry. Capture of this fusion-active conformation of Env provides insights into the early events leading to Env-mediated membrane fusion.

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Citations

Dec 22, 1999·Biochemical and Biophysical Research Communications·J R RyuY G Yu
Mar 18, 2000·Biochemical and Biophysical Research Communications·S Jiang, A K Debnath
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