Capturing Exacerbations of Chronic Obstructive Pulmonary Disease with EXACT. A Subanalysis of FLAME

American Journal of Respiratory and Critical Care Medicine
Stefan M FrentJadwiga A Wedzicha

Abstract

Chronic obstructive pulmonary disease exacerbations accelerate lung function decline, reduce quality of life, and increase mortality. A subset of patients (n = 457) from the FLAME (Effect of Indacaterol Glycopyrronium vs. Fluticasone Salmeterol on COPD Exacerbations) study used the Exacerbations of COPD Tool (EXACT) to capture symptom-defined exacerbations. To evaluate the effect of indacaterol/glycopyrronium versus salmeterol/fluticasone on symptom-defined exacerbations measured using EXACT, and to assess differences between these events and exacerbations requiring healthcare resource use (HCRU). All patients in FLAME used an electronic diary to record and detect symptom deteriorations; HCRU-related exacerbations were confirmed by investigators. In patients using the EXACT questionnaire, the onset, recovery, and magnitude of symptom-defined exacerbations were identified by changes in total scores relative to baseline. We analyzed the annualized rate and time to first symptom-defined (EXACT) exacerbation and assessed differences between symptom-defined and HCRU events in terms of number, severity, and concordance. A nonsignificant 17% reduction in the annualized rate of symptom-defined (EXACT) exacerbations (rate ratio, 0.83; 9...Continue Reading

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Citations

Sep 5, 2020·International Journal of Chronic Obstructive Pulmonary Disease·Konstantinos KostikasJadwiga A Wedzicha
Aug 10, 2018·American Journal of Respiratory and Critical Care Medicine·Marc Miravitlles

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Clinical Trials Mentioned

NCT01782326

Software Mentioned

EXACT
Exacerbations of COPD Tool ( EXACT )
SAS
FLAME EXACT Exacerbations of COPD Tool
FLAME

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