Capturing microscopic features of bone remodeling into a macroscopic model based on biological rationales of bone adaptation

Biomechanics and Modeling in Mechanobiology
Young Kwan KimTaiji Adachi

Abstract

To understand Wolff's law, bone adaptation by remodeling at the cellular and tissue levels has been discussed extensively through experimental and simulation studies. For the clinical application of a bone remodeling simulation, it is significant to establish a macroscopic model that incorporates clarified microscopic mechanisms. In this study, we proposed novel macroscopic models based on the microscopic mechanism of osteocytic mechanosensing, in which the flow of fluid in the lacuno-canalicular porosity generated by fluid pressure gradients plays an important role, and theoretically evaluated the proposed models, taking biological rationales of bone adaptation into account. The proposed models were categorized into two groups according to whether the remodeling equilibrium state was defined globally or locally, i.e., the global or local uniformity models. Each remodeling stimulus in the proposed models was quantitatively evaluated through image-based finite element analyses of a swine cancellous bone, according to two introduced criteria associated with the trabecular volume and orientation at remodeling equilibrium based on biological rationales. The evaluation suggested that nonuniformity of the mean stress gradient in the ...Continue Reading

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Citations

Jan 15, 2018·Journal of Bone and Mineral Metabolism·Justyna Jolanta Miszkiewicz, Patrick Mahoney
Aug 11, 2017·Biomechanics and Modeling in Mechanobiology·C C Villette, A T M Phillips
Jun 13, 2021·Bone·José Manuel García-AznarMaría José Gómez-Benito

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