Capybara Oil Improves Hepatic Mitochondrial Dysfunction, Steatosis, and Inflammation in a Murine Model of Nonalcoholic Fatty Liver Disease

Evidence-based Complementary and Alternative Medicine : ECAM
Polyana C MarinhoJorge J de Carvalho

Abstract

Nonalcoholic fatty liver disease (NAFLD) is recognized as the most common cause of liver dysfunction worldwide and is commonly associated with obesity. Evidences suggest that NAFLD might be a mitochondrial disease, which contributes to the hepatic steatosis, oxidative stress, cytokine release, and cell death. Capybara oil (CO) is a rich source of polyunsaturated fatty acids (PUFA), which is known to improve inflammation and oxidative stress. In order to determine the effects of CO on NAFLD, C57Bl/6 mice were divided into 3 groups and fed a high-fat diet (HFD) (NAFLD group and NAFLD + CO group) or a control diet (CG group) during 16 weeks. The CO (1.5 g/kg/daily) was administered by gavage during the last 4 weeks of the diet protocol. We evaluated plasma liver enzymes, hepatic steatosis, and cytokine expression in liver as well as hepatocyte ultrastructural morphology and mitochondrial function. CO treatment suppressed hepatic steatosis, attenuated inflammatory response, and decreased plasma alanine aminotransferase (ALT) in mice with NAFLD. CO was also capable of restoring mitochondrial ultrastructure and function as well as balance superoxide dismutase and catalase levels. Our findings indicate that CO treatment has positive e...Continue Reading

References

Nov 18, 2000·The New England Journal of Medicine·H Tilg, A M Diehl
Apr 19, 2002·The New England Journal of Medicine·Paul Angulo
Jun 18, 2003·The American Journal of Gastroenterology·Jeanne M ClarkAnna Mae Diehl
Jul 3, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Archana MishraSanjeev Sethi
May 12, 2005·Journal of Hepatology·Dominique Pessayre, Bernard Fromenty
Jan 13, 2006·Mitochondrion·Karima BegricheBernard Fromenty
May 4, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kanji YamaguchiAnna Mae Diehl
Aug 25, 2007·Journal of Gastroenterology and Hepatology·Chien-Hua ChenSen-Kou Yueh
Oct 9, 2007·Alimentary Pharmacology & Therapeutics·E TsochatzisA J Archimandritis
Jan 12, 2008·World Journal of Gastroenterology : WJG·Yongzhong WeiJamal A Ibdah
Sep 6, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Laura H TetriBrent A Neuschwander-Tetri
Feb 3, 2009·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Fernanda A M NascimentoMarcia B Aguila
Jun 2, 2009·Current Opinion in Pharmacology·Shomyseh SanjabiRichard A Flavell
Jan 27, 2010·British Journal of Pharmacology·M C CalixtoE Antunes
Feb 4, 2010·The Journal of Clinical Investigation·Suneil K KoliwadRobert V Farese
Apr 27, 2010·Alimentary Pharmacology & Therapeutics·G S MastertonP C Hayes
May 22, 2010·Journal of Clinical Biochemistry and Nutrition·Julio C FraulobCarlos A Mandarim-de-Lacerda
May 25, 2010·Journal of Hepatology·Vlad RatziuGiulio Marchesini
Oct 28, 2010·Nutrition Research Reviews·Niloofar Hariri, Louise Thibault
Sep 9, 2011·Virchows Archiv : an International Journal of Pathology·Mariana Catta-PretaCarlos Alberto Mandarim-de-Lacerda
Nov 9, 2011·Free Radical Biology & Medicine·Anabela P RoloCarlos M Palmeira
Jan 26, 2012·Indian Journal of Endocrinology and Metabolism·Rakesh M Parikh, Viswanathan Mohan
Jun 12, 2012·PloS One·Alessandra FerramoscaVincenzo Zara
Jun 22, 2012·Journal of the Academy of Nutrition and Dietetics·Erin Marie McCarthy, Mary E Rinella
Dec 5, 2012·Progress in Lipid Research·Giovanni MussoMaurizio Cassader
Jan 30, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R Scott RectorJamal A Ibdah
Feb 1, 2013·Annals of the New York Academy of Sciences·Howard C Masuoka, Naga Chalasani
Jul 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Polyana Cury MarinhoJorge José de Carvalho
Sep 5, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Matthew J ArmstrongWing-Kin Syn
Sep 27, 2013·World Journal of Gastrointestinal Oncology·Rubayat RahmanJamal A Ibdah
May 3, 2014·Current Opinion in Lipidology·M Miriam Jacome-Sosa, Elizabeth J Parks
Jul 16, 2014·World Journal of Gastroenterology : WJG·Maria Del BenFrancesco Angelico
Sep 19, 2014·World Journal of Gastroenterology : WJG·Kareem HassanH Hesham A-Kader
May 17, 2015·Experimental Cell Research·Daniela Caldas de AndradeErika Afonso Costa Cortez
Aug 25, 2015·BioMed Research International·Alessandra FerramoscaVincenzo Zara
Dec 29, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zobair M YounossiMark Wymer
Jan 30, 2016·Metabolism: Clinical and Experimental·Elena BuzzettiEmmanuel A Tsochatzis

❮ Previous
Next ❯

Methods Mentioned

BETA
MDA
electron microscopy

Software Mentioned

Matlab
GraphPad Prism
Image Pro Plus
STEPanizer

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme
Iara Karise Santos MendesTatiana Marlowe Cunha Brunini
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Jamili D B SantosRômulo D Novaes
© 2022 Meta ULC. All rights reserved