CAR-1 and trailer hitch: driving mRNP granule function at the ER?

The Journal of Cell Biology
Carolyn J Decker, Roy Parker

Abstract

The targeting of messenger RNAs (mRNAs) to specific subcellular sites for local translation plays an important role in diverse cellular and developmental processes in eukaryotes, including axis formation, cell fate determination, spindle pole regulation, cell motility, and neuronal synaptic plasticity. Recently, a new conserved class of Lsm proteins, the Scd6 family, has been implicated in controlling mRNA function. Depletion or mutation of members of the Scd6 family, Caenorhabditis elegans CAR-1 and Drosophila melanogaster trailer hitch, lead to a variety of developmental phenotypes, which in some cases can be linked to alterations in the endoplasmic reticulum (ER). Scd6/Lsm proteins are RNA binding proteins and are found in RNP complexes associated with translational control of mRNAs, and these complexes can colocalize with the ER. These findings raise the possibility that localization and translational regulation of mRNAs at the ER plays a role in controlling the organization of this organelle.

References

Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·S Strome, W B Wood
Feb 24, 1997·The Journal of Cell Biology·V I BashkirovW D Heyer
Jan 19, 1999·Annual Review of Cell and Developmental Biology·N K Gray, M Wickens
Jul 4, 2001·Nature Reviews. Molecular Cell Biology·R Mendez, J D Richter
Nov 1, 2001·Annual Review of Cell and Developmental Biology·I M Palacios, D St Johnston
Jan 28, 2004·Cell·Anne Ephrussi, Daniel St Johnston
Feb 26, 2004·Nucleic Acids Research·Nicola Minshall, Nancy Standart
Mar 17, 2004·Genetics·Meenakshi Kshirsagar, Roy Parker
Apr 7, 2004·The Journal of Cell Biology·Nicolas CougotBertrand Séraphin
Jul 1, 2004·FEBS Letters·Mario Albrecht, Thomas Lengauer
Mar 9, 2005·Traffic·Joseph D Mancias, Jonathan Goldberg
Apr 21, 2005·RNA·Maria Alexandra AndreiReinhard Lührmann
Jun 7, 2005·Nature Cell Biology·Jidong LiuRoy Parker
Jun 22, 2005·The Journal of Cell Biology·Nancy KedershaPaul Anderson
Jun 28, 2005·Biochimica Et Biophysica Acta·Bor Luen TangWanjin Hong
Jun 30, 2005·Genesis : the Journal of Genetics and Development·Rosa E Navarro, T Keith Blackwell
Jul 30, 2005·Trends in Biochemical Sciences·Permanan KhusialGary W Zieve
Aug 5, 2005·Nature·Henrik Bringmann, Anthony A Hyman
Aug 6, 2005·Science·Ramesh S PillaiWitold Filipowicz
Sep 24, 2005·Cell·Jeff Coller, Roy Parker
Nov 15, 2005·Nature Cell Biology·Andrew JakymiwEdward K L Chan
Dec 6, 2005·Nature Structural & Molecular Biology·Carol J Wilusz, Jeffrey Wilusz
Dec 21, 2005·Molecular Cell·Martin Fenger-GrønJens Lykke-Andersen

❮ Previous
Next ❯

Citations

Jul 9, 2009·Nature Reviews. Neuroscience·Arthur H M Burghes, Christine E Beattie
Sep 5, 2008·Molecular Biology of the Cell·Hélène Gaillard, Andrés Aguilera
Jun 4, 2010·Molecular Biology of the Cell·Cornelia KilchertAnne Spang
Apr 27, 2013·Nucleic Acids Research·Anna GoliszJoanna Kufel
Dec 20, 2013·Genes & Development·Stefanie Jonas, Elisa Izaurralde
Nov 25, 2011·Development, Growth & Differentiation·Yasuko Kato, Akira Nakamura
Jul 5, 2007·Journal of Virology·Carla J BeckhamAmine Noueiry
Jul 20, 2011·Molecular and Cellular Biology·Subramanya SrikantanMyriam Gorospe
Dec 7, 2007·PLoS Biology·Alexander F PalazzoTom A Rapoport
Aug 2, 2012·The Journal of Cell Biology·Jonathan C ReedJaisri R Lingappa
Mar 30, 2010·Trends in Biochemical Sciences·Judith Kraut-Cohen, Jeffrey E Gerst
Nov 7, 2006·Trends in Biochemical Sciences·Kevin Czaplinski, Robert H Singer
Aug 30, 2008·The International Journal of Biochemistry & Cell Biology·Aline MarnefMichael R Ladomery
Mar 21, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Mark J Snee, Paul M Macdonald
Sep 18, 2007·Genesis : the Journal of Genetics and Development·L Silvia SalinasRosa E Navarro
Mar 17, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·François ProdonYasunori Sasakura
Apr 11, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Christian SardetJanet Chenevert
Feb 14, 2014·Wiley Interdisciplinary Reviews. RNA·Jennifer A Schisa
Oct 4, 2013·The Biochemical Journal·Marina CristoderoIsabel Roditi
May 23, 2012·RNA Biology·Ken MatsumotoMasafumi Tsujimoto
Dec 9, 2008·Molecular Cell·Tobias M Franks, Jens Lykke-Andersen
Jul 4, 2020·Genes & Development·Dasa LongmanJavier F Cáceres
Mar 16, 2019·Frontiers in Plant Science·Rafael CataláJulio Salinas
Nov 1, 2006·The Journal of Biological Chemistry·Kimio J TanakaMasafumi Tsujimoto
Feb 6, 2017·BMC Genomics·Aliaksandr A YarmishynIgor V Kurochkin
Jun 19, 2016·G3 : Genes - Genomes - Genetics·Megan P WoodJennifer A Schisa

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