CAR T cell therapy.

Immunological Medicine
Naoki Hosen

Abstract

Chimeric antigen receptor (CAR) is generated by fusing a cancer-specific antibody's antigen recognition site with costimulatory molecules such as CD28 and CD3ζ. T cells transduced with CAR recognizes cancer-specific antigens and kill cancer cells. The effect of CD19-targeted CAR T cells on B-cell hematologic cancer is surprising and has already been approved in many countries including Japan. More targets for several kinds of cancers are being searched now. We have also shown that CAR T cells specific for activated integrin β7 are highly effective for multiple myeloma in pre-clinical tests.

References

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Oct 16, 2014·The New England Journal of Medicine·Shannon L MaudeStephan A Grupp
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Jul 5, 2018·The New England Journal of Medicine·Carl H June, Michel Sadelain
Mar 22, 2019·The Journal of Clinical Investigation·Adam D CohenMichael C Milone
Mar 29, 2019·Science Translational Medicine·Eric L SmithRenier J Brentjens
Apr 17, 2019·Proceedings of the National Academy of Sciences of the United States of America·Jie XuSai-Juan Chen
May 3, 2019·The New England Journal of Medicine·Noopur RajeJames N Kochenderfer

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