Abstract
A novel nor-phragmalin-type limonoid, named carapanosin D (1), and two novel mexicanolide-type limonoids, carapanosins E (2) and F (3), were isolated from the seed oil of andiroba (Carapa guianensis Aublet), a traditional medicine in Brazil and Latin American countries. Their structures were unambiguously determined on the basis of spectroscopic analyses using one-dimensional (1D) and two-dimensional (2D) NMR techniques and High resolution Fast Atom Bombardment Mass Spectrometry (HRFABMS). Compounds 1⁻3 were evaluated for their effects on the production of nitric oxide (NO) in Lipopolysaccharide (LPS)-activated mouse peritoneal macrophages. The NO inhibitory assay suggested that compounds 2 and 3 have high potency as inhibitors of macrophage activation.
References
Sep 1, 2005·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·C PenidoM G M O Henriques
Nov 24, 2006·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·C PenidoM G M O Henriques
Feb 3, 2009·Chemical Reviews·Shang-Gao LiaoJian-Min Yue
Oct 19, 2010·International Immunopharmacology·Fausto K FerrarisMaria das Graças M O Henriques
Jun 7, 2011·Bioorganic & Medicinal Chemistry·Takeshi YamadaReiko Tanaka
Sep 8, 2011·Chemical Reviews·Qin-Gang Tan, Xiao-Dong Luo
Jun 5, 2012·Journal of Ethnopharmacology·Raimundo Nonato Cardoso Miranda JúniorJosé Guilherme S Maia
Jun 6, 2013·Organic Letters·Takanobu InoueReiko Tanaka
Apr 22, 2014·Fitoterapia·Takanobu InoueReiko Tanaka
Aug 16, 2014·Malaria Journal·Tiago B PereiraAdrian M Pohlit
Sep 10, 2014·Fitoterapia·Asami SakamotoReiko Tanaka
Oct 28, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuuki MatsuiReiko Tanaka
Nov 28, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Teppei MiyakeReiko Tanaka
Mar 23, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Keiichiro HiguchiReiko Tanaka
Oct 11, 2017·Chemistry, an Asian Journal·Keiichiro HiguchiReiko Tanaka